• 336 Citations
  • 11 h-Index
1996 …2024
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Research Output 1996 2019

  • 336 Citations
  • 11 h-Index
  • 24 Article
  • 8 Patent
  • 1 Editorial
  • 1 Review article
2019

Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention

Zhang, D., Leal, A. S., Carapellucci, S., Shahani, P. H., Bhogal, J. S., Ibrahim, S., Raban, S., Jurutka, P., Marshall, P., Sporn, M. B., Wagner, C. & Liby, K. T., Apr 1 2019, In : Cancer Prevention Research. 12, 4, p. 211-224 14 p.

Research output: Contribution to journalArticle

Neoplasms
Sterol Regulatory Element Binding Proteins
Retinoid X Receptors
Lung
Hepatomegaly
2018
1 Citation (Scopus)

A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics

Hanish, B. J., Hackney Price, J., Kaneko, I., Ma, N., van der Vaart, A., Wagner, C., Jurutka, P. & Marshall, P., Jul 1 2018, In : Steroids. 135, p. 36-49 14 p.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
Neoplasms
Cutaneous T-Cell Lymphoma
T-cells
Ebolavirus
Herpes Simplex
Vaccinia virus
Antiviral Agents
Metals

Dataset on the response of Hut78 cells to novel rexinoids

Hackney Price, J., Hanish, B. J., Wagner, C., Kaneko, I., Jurutka, P. & Marshall, P., Oct 1 2018, In : Data in Brief. 20, p. 1797-1803 7 p.

Research output: Contribution to journalArticle

Gene Expression
Cutaneous T-Cell Lymphoma
Retinoids
Response Elements
Genetic Promoter Regions
2017
2 Citations (Scopus)

Molecular dynamics simulations and molecular flooding studies of the retinoid X-receptor ligand binding domain

Gray, G. M., Ma, N., Wagner, C. & van der Vaart, A., Mar 1 2017, In : Journal of Molecular Modeling. 23, 3, 98.

Research output: Contribution to journalArticle

Retinoid X Receptors
Molecular dynamics
Ligands
molecular dynamics
ligands
6 Citations (Scopus)

Retinoid x receptor selective agonists and their synthetic methods

Wagner, C., Jurutka, P., Marshall, P. & Heck, M. C., Mar 1 2017, In : Current Topics in Medicinal Chemistry. 17, 6, p. 742-767 26 p.

Research output: Contribution to journalReview article

Retinoid X Receptors
Retinoids
Cytoplasmic and Nuclear Receptors
Retinoic Acid Receptors
Calcitriol Receptors

Rexinoids

Wagner, C., Marshall, P. & Jurutka, P., Mar 1 2017, In : Current Topics in Medicinal Chemistry. 17, 6, p. 629-630 2 p.

Research output: Contribution to journalEditorial

Retinoid X Receptors
2016
11 Citations (Scopus)

Aspartate β-hydroxylase modulates cellular senescence through glycogen synthase kinase 3β in hepatocellular carcinoma

Iwagami, Y., Huang, C. K., Olsen, M. J., Thomas, J. M., Jang, G., Kim, M., Lin, Q., Carlson, R. I., Wagner, C., Dong, X. & Wands, J. R., Apr 1 2016, In : Hepatology. 63, 4, p. 1213-1226 14 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Cell Aging
Mixed Function Oxygenases
Aspartic Acid
Hepatocellular Carcinoma
5 Citations (Scopus)

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)

Heck, M. C., Wagner, C., Shahani, P. H., Macneill, M., Grozic, A., Darwaiz, T., Shimabuku, M., Deans, D. G., Robinson, N. M., Salama, S. H., Ziller, J. W., Ma, N., Van Der Vaart, A., Marshall, P. & Jurutka, P., Oct 13 2016, In : Journal of Medicinal Chemistry. 59, 19, p. 8924-8940 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Niacin
Cutaneous T-Cell Lymphoma
Retinoic Acid Receptors
2015
12 Citations (Scopus)

Analysis of differential secondary effects of novel rexinoids: Select rexinoid X receptor ligands demonstrate differentiated side effect profiles

Marshall, P., Jurutka, P., Wagner, C., van der Vaart, A., Kaneko, I., Chavez, P. I., Ma, N., Bhogal, J. S., Shahani, P., Swierski, J. C. & Macneill, M., Mar 1 2015, In : Pharmacology Research and Perspectives. 3, 2, p. 1-19 19 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Ligands
RNA Sequence Analysis
Lipids
Thyrotropin
1 Citation (Scopus)

Distinct functional modes of SUMOylation for retinoid X receptor alpha

Lee, W. P., Jena, S., Rodriguez, E. P., O'Donovan, S. P., Wagner, C., Jurutka, P. & Thompson, P. D., Jul 20 2015, In : Biochemical and Biophysical Research Communications. 464, 1, p. 195-200 6 p.

Research output: Contribution to journalArticle

Retinoid X Receptor alpha
Sumoylation
Lysine
Protein Inhibitors of Activated STAT
Ubiquitin
Retinoid X Receptors
Alzheimer Disease
Neurodegenerative Diseases
Parkinson Disease
bexarotene
Retinoid X Receptors
Alzheimer Disease
Neurodegenerative Diseases
Parkinson Disease
galantide
2014

Compounds to Modulate RXR

Jurutka, P., Marshall, P. & Wagner, C., Jan 8 2014

Research output: Patent

Retinoid X Receptors
Alzheimer Disease
Neurodegenerative Diseases
Parkinson Disease
bexarotene
2013
Patents
Retinoid X Receptors
Parkinson Disease
Alzheimer Disease
Neurodegenerative Diseases
15 Citations (Scopus)

Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl) -4-hydroxyphenyl)acrylic acid (CD3254)

Jurutka, P., Kaneko, I., Yang, J., Bhogal, J. S., Swierski, J. C., Tabacaru, C. R., Montano, L. A., Huynh, C. C., Jama, R. A., Mahelona, R. D., Sarnowski, J. T., Marcus, L. M., Quezada, A., Lemming, B., Tedesco, M. A., Fischer, A. J., Mohamed, S. A., Ziller, J. W., Ma, N., Gray, G. M. & 3 othersVan Der Vaart, A., Marshall, P. & Wagner, C., Nov 14 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8432-8454 23 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Cutaneous T-Cell Lymphoma
Retinoic Acid Receptors
Drug Design
11 Citations (Scopus)

Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists

Batie, S., Lee, J. H., Jama, R. A., Browder, D. O., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Mohammed, Z., Trang, V., Marshall, P., Jurutka, P. & Wagner, C., Feb 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 3, p. 693-702 10 p.

Research output: Contribution to journalArticle

Curcumin
Cytoplasmic and Nuclear Receptors
Calcitriol Receptors
Retinoid X Receptors
Assays
6 Citations (Scopus)
Curcumin
Biological Products
Hydrogenation
Spectroscopy
Students
2012
21 Citations (Scopus)

Modeling, Synthesis and Biological Evaluation of Potential RetinoidX Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)

Furmick, J. K., Kaneko, I., Walsh, A. N., Yang, J., Bhogal, J. S., Gray, G. M., Baso, J. C., Browder, D. O., Prentice, J. L. S., Montano, L. A., Huynh, C. C., Marcus, L. M., Tsosie, D. G., Kwon, J. S., Quezada, A., Reyes, N. M., Lemming, B., Saini, P., vanderVaart, A., Groy, T. L. & 3 othersMarshall, P., Jurutka, P. & Wagner, C., Sep 2012, In : ChemMedChem. 7, 9, p. 1551-1566 16 p.

Research output: Contribution to journalArticle

Benzoic Acid
Assays
Cutaneous T-Cell Lymphoma
Halogens
T-cells

Therapeutic Compounds

Jurutka, P., Marshall, P. & Wagner, C., Aug 17 2012

Research output: Patent

Retinoid X Receptors
Therapeutics
Alzheimer Disease
Neurodegenerative Diseases
Parkinson Disease
2011
15 Citations (Scopus)

Extraction, purification, and spectroscopic characterization of a mixture of capsaicinoids

Wagner, C., Cahill, T. & Marshall, P., Nov 1 2011, In : Journal of Chemical Education. 88, 11, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Purification
Students
Nuclear magnetic resonance
student
Thin layer chromatography
Retinoid X Receptors
Alzheimer Disease
Neurodegenerative Diseases
Parkinson Disease
bexarotene
Retinoid X Receptors
Alzheimer Disease
Neoplasms
Inventors
Therapeutics
2010
1 Citation (Scopus)

2-Fluoro-4-(methoxycarbonyl)benzoic acid

Wagner, C. & Groy, T. L., Sep 2010, In : Acta Crystallographica Section E: Structure Reports Online. 66, 9

Research output: Contribution to journalArticle

Benzoic Acid
Benzoic acid
benzoic acid
Dihedral angle
Benzene
4 Citations (Scopus)

Synthesis of 2, 5-Dichloro-2, 5-dimethylhexane by an SN1 reaction

Wagner, C. & Marshall, P., Jan 2010, In : Journal of Chemical Education. 87, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

2009
42 Citations (Scopus)

Modeling, synthesis and biological evaluation of potential Retinoid X Receptor (RXR) selective agonists: Novel analogues of 4-[1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)

Wagner, C., Jurutka, P., Marshall, P., Groy, T. L., Van Der Vaart, A., Ziller, J. W., Furmick, J. K., Graeber, M. E., Matro, E., Miguel, B. V., Tran, I. T., Kwon, J., Tedeschi, J. N., Moosavi, S., Danishyar, A., Philp, J. S., Khamees, R. O., Jackson, J. N., Grupe, D. K., Badshah, S. L. & 1 othersHart, J. W., Oct 8 2009, In : Journal of Medicinal Chemistry. 52, 19, p. 5950-5966 17 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Apoptosis
Cutaneous T-Cell Lymphoma
Drug Design
Retinoid X Receptors
Alzheimer Disease
Neurodegenerative Diseases
Parkinson Disease
bexarotene
2008
10 Citations (Scopus)

Synthesis and biological evaluation of analogs of altohyrtin C (spongistatin 2)

Wagner, C., Wang, Q., Melamed, A., Fairchild, C. R., Wild, R. & Heathcock, C. H., Jan 1 2008, In : Tetrahedron. 64, 1, p. 124-136 13 p.

Research output: Contribution to journalArticle

Cytotoxicity
Inhibitory Concentration 50
HCT116 Cells
Cells
Colon
2005
29 Citations (Scopus)

Synthesis of linear α-olefins via polyhomologation

Wagner, C., Rodriguez, A. A. & Shea, K. J., Aug 23 2005, In : Macromolecules. 38, 17, p. 7286-7291 6 p.

Research output: Contribution to journalArticle

Alkenes
Olefins
Molecular weight
Polymers
Troleandomycin
2004
5 Citations (Scopus)

Synthesis and First Molecular Structure of a Bis-2-spiro-1-boraadamantane Derivative

Wagner, C. & Shea, K. J., Feb 5 2004, In : Organic Letters. 6, 3, p. 313-316 4 p.

Research output: Contribution to journalArticle

Molecular Structure
Molecular structure
pyridines
molecular structure
Lewis Bases
2003
19 Citations (Scopus)

Synthesis of 1-boraadamantaneamine derivatives with selective astrocyte vs C6 glioma antiproliferative activity. A novel class of anti-hepatitis C agents with potential to bind CD81

Wagner, C., Mohler, M. L., Kang, G. S., Miller, D. D., Geisert, E. E., Chang, Y. A., Fleischer, E. B. & Shea, K. J., Jul 3 2003, In : Journal of Medicinal Chemistry. 46, 14, p. 2823-2833 11 p.

Research output: Contribution to journalArticle

Hepatitis C
Glioma
Astrocytes
Virus Attachment
Cell Line
53 Citations (Scopus)

The polyhomologation of 1-boraadamantane: Mapping the migration pathways of a propagating macrotricyclic trialkylborane

Wagner, C., Kim, J. S. & Shea, K. J., Oct 8 2003, In : Journal of the American Chemical Society. 125, 40, p. 12179-12195 17 p.

Research output: Contribution to journalArticle

Polymerization
Polymers
Boron
Molecular modeling
Polydispersity
2001
32 Citations (Scopus)

1-Boraadamantane blows its top, sometimes. The mono-and polyhomologation of 1-boraadamantane

Wagner, C. & Shea, K. J., Oct 4 2001, In : Organic Letters. 3, 20, p. 3063-3066 4 p.

Research output: Contribution to journalArticle

Polymerization
polymerization
Boron
initiators
products
1996
35 Citations (Scopus)

Reactivity of ester linkages and pentaammineruthenium(III) at the monolayer assembly/solution interface

Van Ryswyk, H., Turtle, E. D., Watson-Clark, R., Tanzer, T. A., Herman, T. K., Chong, P. Y., Waller, P. J., Taurog, A. L. & Wagner, C., Dec 11 1996, In : Langmuir. 12, 25, p. 6143-6150 8 p.

Research output: Contribution to journalArticle

linkages
hydrolysis
esters
Monolayers
Esters