Bertram Jacobs

Director & Professor

  • 5982 Citations
  • 43 h-Index
1900 …2019
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Research Output 1900 2019

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Article
2005
98 Citations (Scopus)

Evidence for emergence of an amphibian iridoviral disease because of human-enhanced spread

Jancovich, J. K., Davidson, E. W., Parameswaran, N., Mao, J., Chinchar, V. G., Collins, J., Jacobs, B. & Storfer, A., Jan 2005, In : Molecular Ecology. 14, 1, p. 213-224 12 p.

Research output: Contribution to journalArticle

Iridovirus
Capsid Proteins
Amphibians
Urodela
human diseases
45 Citations (Scopus)

The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response

Brandt, T., Heck, M. C., Vijaysri, S., Jentarra, G. M., Cameron, J. M. & Jacobs, B., Mar 15 2005, In : Virology. 333, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

Vaccinia virus
Smallpox
Viruses
Nose
Mucosal Immunity
2004
72 Citations (Scopus)

Inhibition of PKR by vaccinia virus: Role of the N- and C-terminal domains of E3L

Langland, J. & Jacobs, B., Jul 1 2004, In : Virology. 324, 2, p. 419-429 11 p.

Research output: Contribution to journalArticle

Vaccinia virus
Phosphorylation
Antiviral Agents
Peptide Initiation Factors
Double-Stranded RNA
31 Citations (Scopus)

Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection

Kibler, K., Miyazato, A., Yedavalli, V. S. R. K., Dayton, A. I., Jacobs, B., Dapolito, G., Kim, S. J. & Jeang, K. T., Nov 19 2004, In : Journal of Biological Chemistry. 279, 47, p. 49055-49063 9 p.

Research output: Contribution to journalArticle

Furin
Virus Diseases
Viruses
HIV-1
Processing
41 Citations (Scopus)

Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia

Auch, C. J., Saha, R. N., Sheikh, F. G., Liu, X., Jacobs, B. & Pahan, K., Apr 9 2004, In : FEBS Letters. 563, 1-3, p. 223-228 6 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Nitric Oxide Synthase Type II
Nitric Oxide Synthase
Astrocytes
Protein Kinases
2003
147 Citations (Scopus)

A role for Z-DNA binding in vaccinia virus pathogenesis

Kim, Y. G., Muralinath, M., Brandt, T., Pearcy, M., Hauns, K., Lowenhaupt, K., Jacobs, B. & Rich, A., Jun 10 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 12, p. 6974-6979 6 p.

Research output: Contribution to journalArticle

Z-Form DNA
Vaccinia virus
Smallpox
Viruses
Mutation
116 Citations (Scopus)

Genomic sequence of a ranavirus (family Iridoviridae) associated with salamander mortalities in North America

Jancovich, J. K., Mao, J., Chinchar, V. G., Wyatt, C., Case, S. T., Kumar, S., Valente, G., Subramanian, S., Davidson, E. W., Collins, J. & Jacobs, B., Nov 10 2003, In : Virology. 316, 1, p. 90-103 14 p.

Research output: Contribution to journalArticle

Iridoviridae
Ranavirus
Urodela
North America
Ambystoma
3 Citations (Scopus)
Nuclear Factor 90 Proteins
Vaccinia virus
Interleukin-2
Gene Expression
Double-Stranded RNA
18 Citations (Scopus)

The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo

Vijaysri, S., Talasela, L., Mercer, A. A., Mcinnes, C. J., Jacobs, B. & Langland, J., Sep 15 2003, In : Virology. 314, 1, p. 305-314 10 p.

Research output: Contribution to journalArticle

Orf virus
Vaccinia virus
Genes
Open Reading Frames
Lethal Dose 50
2002
140 Citations (Scopus)

Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus

Xiang, Y., Condit, R. C., Vijaysri, S., Jacobs, B., Williams, B. R. G. & Silverman, R. H., 2002, In : Journal of Virology. 76, 10, p. 5251-5259 9 p.

Research output: Contribution to journalArticle

Vaccinia virus
RNA-binding proteins
RNA-Binding Proteins
double-stranded RNA
interferons
146 Citations (Scopus)

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase

He, Y., Nakao, H., Tan, S. L., Polyak, S. J., Neddermann, P., Vijaysri, S., Jacobs, B. & Katze, M. G., Sep 2002, In : Journal of Virology. 76, 18, p. 9207-9217 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Hepatitis C virus
Growth Factor Receptors
phosphatidylinositol 3-kinase
growth factors
118 Citations (Scopus)

The role of the PKR-inhibitory genes, E3L and K3L, in determining vaccinia virus host range

Langland, J. & Jacobs, B., 2002, In : Virology. 299, 1, p. 133-141 9 p.

Research output: Contribution to journalArticle

Vaccinia virus
Host Specificity
Double-Stranded RNA
eIF-2 Kinase
Genes
2001
156 Citations (Scopus)
Vaccinia virus
interferons
Interferons
pathogenesis
animal models
50 Citations (Scopus)

Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A

He, Y., Tan, S. L., Tareen, S. U., Vijaysri, S., Langland, J., Jacobs, B. & Katze, M. G., 2001, In : Journal of Virology. 75, 11, p. 5090-5098 9 p.

Research output: Contribution to journalArticle

cell communication
Hepatitis C virus
Protein Biosynthesis
Hepacivirus
protein kinases
62 Citations (Scopus)

Transmission of the Ambystoma tigrinum virus to alternative hosts

Jancovich, J. K., Davidson, E. W., Seiler, A., Jacobs, B. & Collins, J., Oct 8 2001, In : Diseases of Aquatic Organisms. 46, 3, p. 159-163 5 p.

Research output: Contribution to journalArticle

Ambystoma tigrinum virus
alternative hosts
virus
salamanders and newts
frogs
48 Citations (Scopus)

Vaccinia virus E3L interferon resistance protein inhibits the interferon-induced adenosine deaminase A-to-I editing activity

Liu, Y., Wolff, K. C., Jacobs, B. & Samuel, C. E., Oct 25 2001, In : Virology. 289, 2, p. 378-387 10 p.

Research output: Contribution to journalArticle

Z-Form DNA
Adenosine Deaminase
Vaccinia virus
Interferons
RNA Precursors
1999
203 Citations (Scopus)
GRB2 Adaptor Protein
src Homology Domains
Protein C
Hepacivirus
Ligands
92 Citations (Scopus)
Nuclear Factor 90 Proteins
eIF-2 Kinase
NFATC Transcription Factors
RNA-Binding Proteins
T-cells
1998
41 Citations (Scopus)

Activation of antiviral protein kinase leads to immunoglobulin E class switching in human B cells

Rager, K. J., Langland, J., Jacobs, B., Proud, D., Marsh, D. G. & Imani, F., Feb 1998, In : Journal of Virology. 72, 2, p. 1171-1176 6 p.

Research output: Contribution to journalArticle

antiviral proteins
Immunoglobulin Class Switching
immunoglobulin E
protein kinases
Protein Kinases

Anti viral protein kinase (PKR) modulates expression of Th2-type responses

Imani, F., Everest, A. R., Jacobs, B., Proud, D. & Marsh, D. G., Mar 20 1998, In : FASEB Journal. 12, 5

Research output: Contribution to journalArticle

antiviral proteins
eIF-2 Kinase
Viral Proteins
protein kinases
Immunoglobulin E
14 Citations (Scopus)

Characterization of viral double-stranded RNA-binding proteins

Jacobs, B., Langland, J. & Brandt, T., 1998, In : Methods: A Companion to Methods in Enzymology. 15, 3, p. 225-232 8 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Viral RNA
Viral Proteins
Viruses
Virus Activation
29 Citations (Scopus)
Orthoreovirus
Reoviridae
eIF-2 Kinase
RNA-Binding Proteins
Double-Stranded RNA
40 Citations (Scopus)

Role of the vaccinia virus E3L and K3L gene products in rescue of VSV and EMCV from the effects of IFN-α

Shors, S. T., Beattie, E., Paoletti, E., Tartaglia, J. & Jacobs, B., Sep 1998, In : Journal of Interferon and Cytokine Research. 18, 9, p. 721-729 9 p.

Research output: Contribution to journalArticle

Encephalomyocarditis virus
Vesicular Stomatitis
Vaccinia virus
Interferons
Viruses
1997
21 Citations (Scopus)

Complementation of deletion of the vaccinia virus E3L gene by the Escherichia coli RNase III gene

Shors, T. & Jacobs, B., Jan 6 1997, In : Virology. 227, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

Ribonuclease III
Vaccinia virus
Escherichia coli
Genes
Host Specificity
51 Citations (Scopus)

Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L

Shors, T., Kibler, K., Perkins, K. B., Seidler-Wulff, R., Banaszak, M. P. & Jacobs, B., Dec 22 1997, In : Virology. 239, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

Vaccinia virus
HeLa Cells
Interferons
Genes
Viruses
165 Citations (Scopus)

Double-stranded RNA is a trigger for apoptosis in vaccinia virus- infected cells

Kibler, K., Shors, T., Perkins, K. B., Zeman, C. C., Banaszak, M. P., Biesterfeldt, J., Langland, J. & Jacobs, B., Mar 1997, In : Journal of Virology. 71, 3, p. 1992-2003 12 p.

Research output: Contribution to journalArticle

Vaccinia virus
Double-Stranded RNA
double-stranded RNA
apoptosis
Apoptosis
168 Citations (Scopus)

Isolation of a lethal virus from the endangered tiger salamander Ambystoma tigrinum stebbinsi

Jancovich, J. K., Davidson, E. W., Frank Morado, J., Jacobs, B. & Collins, J., Dec 30 1997, In : Diseases of Aquatic Organisms. 31, 3, p. 161-167 7 p.

Research output: Contribution to journalArticle

Ambystoma tigrinum
Ambystoma
salamanders and newts
virus
viruses
1996
91 Citations (Scopus)

Host-range restriction of vaccinia virus E3L-specific deletion mutants

Beattie, E., Kauffman, E. B., Martinez, H., Perkus, M. E., Jacobs, B., Paoletti, E. & Tartaglia, J., 1996, In : Virus Genes. 12, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

Vaccinia virus
Host Specificity
Viruses
Carrier Proteins
Mammalian orthoreovirus 3
486 Citations (Scopus)

When Two Strands Are Better Than One: The Mediators and Modulators of the Cellular Responses to Double-Stranded RNA

Jacobs, B. & Langland, J., May 15 1996, In : Virology. 219, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Interferon Inducers
Virus Diseases
Interferons
Antiviral Agents
1995
84 Citations (Scopus)

Atomic force microscopy of nucleoprotein complexes

Lyubchenko, Y. L., Jacobs, B., Lindsay, S., Stasiak, A., Hansma, H. G., Fritzsche, W., Schaper, A. & Shao, Z., 1995, In : Scanning Microscopy. 9, 3, p. 705-727 23 p.

Research output: Contribution to journalArticle

Atomic force microscopy
DNA
deoxyribonucleic acid
atomic force microscopy
proteins
49 Citations (Scopus)

Identification of a plant-encoded analog of PKR, the mammalian double-stranded RNA-dependent protein kinase

Langland, J., Jin, S., Jacobs, B. & Roth, D. A., Jul 1995, In : Plant Physiology. 108, 3, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Double-Stranded RNA
double-stranded RNA
protein kinases
antiserum
27 Citations (Scopus)

Nucleic Acid Affinity Chromatography: Preparation and Characterization of Double-Stranded RNA Agarose

Langland, J., Pettiford, S. M. & Jacobs, B., Feb 1995, In : Protein Expression and Purification. 6, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Affinity chromatography
Double-Stranded RNA
Affinity Chromatography
Sepharose
Nucleic Acids
93 Citations (Scopus)

Rescue of vaccinia virus lacking the E3L gene by mutants of E3L

Chang, H. W., Uribe, L. H. & Jacobs, B., 1995, In : Journal of Virology. 69, 10, p. 6605-6608 4 p.

Research output: Contribution to journalArticle

Vaccinia virus
mutants
Double-Stranded RNA
Host Specificity
double-stranded RNA
154 Citations (Scopus)

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene

Beattie, E., Denzler, K. L., Tartaglia, J., Perkus, M. E., Paoletti, E. & Jacobs, B., Jan 1995, In : Journal of Virology. 69, 1, p. 499-505 7 p.

Research output: Contribution to journalArticle

Vaccinia virus
Reoviridae
interferons
Interferons
double-stranded RNA
1994
22 Citations (Scopus)
Isocitrate Lyase
Cottonseed Oil
Peroxisomes
Amino Acid Substitution
Plant Proteins
72 Citations (Scopus)
Rotavirus C
eIF-2 Kinase
RNA-Binding Proteins
Double-Stranded RNA
Rotavirus
42 Citations (Scopus)

Site-Directed Mutagenic Analysis of Reovirus σ3 Protein Binding to dsRNA

Denzler, K. L. & Jacobs, B., Oct 1994, In : Virology. 204, 1, p. 190-199 10 p.

Research output: Contribution to journalArticle

Mammalian orthoreovirus 3
Protein Binding
Amino Acids
Proteins
COS Cells
164 Citations (Scopus)

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR

Park, H., Davies, M. V., Langland, J., Chang, H. W., Nam, Y. S., Tartaglia, J., Paoletti, E., Jacobs, B., Kaufman, R. J. & Venkatesan, S., May 24 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 11, p. 4713-4717 5 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
RNA-Binding Proteins
Response Elements
Interferons
Transcriptional Activation
1993
129 Citations (Scopus)

Identification of a Conserved Motif That Is Necessary for Binding of the Vaccinia Virus E3L Gene Products to Double-Stranded RNA

Chang, H. W. & Jacobs, B., Jun 1993, In : Virology. 194, 2, p. 537-547 11 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Vaccinia virus
Genes
Phosphotransferases
Proteins
43 Citations (Scopus)

PKR: Proposed nomenclature for the RNA-dependent protein kinase induced by interferon

Clemens, M. J., Hershey, J. W. B., Hovanessian, A. C., Jacobs, B., Katze, M. G., Kaufman, R. J., Lengyel, P., Samuel, C. E., Sen, G. C. & Williams, B. R. G., 1993, In : Journal of Interferon Research. 13, 3, p. 241 1 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Protein-Serine-Threonine Kinases
Terminology
Interferons
210 Citations (Scopus)

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

Davies, M. V., Chang, H. W., Jacobs, B. & Kaufman, R. J., Mar 1993, In : Journal of Virology. 67, 3, p. 1688-1692 5 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Vaccinia virus
Double-Stranded RNA
double-stranded RNA
protein kinases
22 Citations (Scopus)

The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR

Baier, L. J., Shors, T., Shors, S. T. & Jacobs, B., Oct 11 1993, In : Nucleic Acids Research. 21, 20, p. 4830-4835 6 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Interferons
Protein Kinase
Double-Stranded RNA
RNA
1992
138 Citations (Scopus)

Atomic force microscopy imaging of double stranded DNA and RNA

Lyubchenko, Y. L., Jacobs, B., Shlyakhtenko, L. S., Harrington, R. E., Jacobs, B. L., Oden, P. I. & Lindsay, S., 1992, In : Journal of Biomolecular Structure and Dynamics. 10, 3, p. 589-606 18 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Atomic Force Microscopy
DNA
Silanes
Air
84 Citations (Scopus)

Atomic force microscopy of reovirus dsRNA: A routine technique for length measurements

Lyubchenko, Y. L., Jacobs, B. & Lindsay, S., Aug 11 1992, In : Nucleic Acids Research. 20, 15, p. 3983-3986 4 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Atomic Force Microscopy
RNA
Atomic force microscopy
Electron Microscopy
83 Citations (Scopus)
eIF-2 Kinase
Double-Stranded RNA
Dimers
Phosphotransferases
Ribosomes
377 Citations (Scopus)
eIF-2 Kinase
Double-Stranded RNA
Vaccinia virus
Interferons
Genes
1991
98 Citations (Scopus)
eIF-2 Kinase
RNA-Binding Proteins
Double-Stranded RNA
Vaccinia virus
Phosphotransferases
27 Citations (Scopus)

The lang strain of reovirus serotype 1 and the dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon

Jacobs, B. & Ferguson, R. E., Sep 1991, In : Journal of Virology. 65, 9, p. 5102-5104 3 p.

Research output: Contribution to journalArticle

Mammalian Orthoreovirus
Mammalian orthoreovirus 3
interferon-beta
Reoviridae
Interferon-beta
1988
10 Citations (Scopus)
Double-Stranded RNA
Protein Binding
Histones
Protein Kinases
Interferons
141 Citations (Scopus)
Mammalian Orthoreovirus
Protein Kinases
Interferons
Phosphotransferases
Double-Stranded RNA