Mechanisms of Evolution, Center for (ME)

Projects

Projects per year 2017 2017 2018 2019 2020 2021 2026

• 12 Active
• 14 Finished

Projects per year

Search results

• Active

  Models for the Evolution of Symbiosis

  Lynch, M.

  Gordon and Betty Moore Foundation

  8/29/23 → 8/31/25

  Project: Research project

  • symbiosis 100%

• A bacterial pathway within: defining the function of plant peptidoglycan genes

  McCutcheon, J.

  Howard Hughes Medical Institute (HHMI)

  9/20/22 → 9/19/26

  Project: Research project

  • biology 100%
  • traineeship 46%
  • graduate 43%
  • import 35%
  • France 30%

• Untangling the complex roles of the basal body cytoskeleton in the origin and diversification of meiosis, mitosis, and flagellar function

  Wideman, J.

  Gordon and Betty Moore Foundation

  10/5/21 → 10/1/24

  Project: Research project

  • cytoskeleton 100%
  • mitosis 90%
  • meiosis 89%
  • proteomics 41%

• Cellular mechanisms that modify the impacts of mutation

  Geiler-Samerotte, K.

  Sloan (Alfred P.) Foundation

  9/15/21 → 9/14/25

  Project: Research project

  • Mutation 100%
  • Costs and Cost Analysis 23%
  • Yeasts 22%
  • Phenotype 22%
  • Genotype 20%

• BII: Mechanisms of Cellular Evolution

  Lynch, M., Hu, K., Wideman, J., Geiler-Samerotte, K. & Frasch, W.

  National Science Foundation (NSF)

  9/1/21 → 8/31/26

  Project: Research project

  • cell biology 100%
  • population genetics 83%
  • evolutionary biology 83%
  • structural biology 70%
  • energy metabolism 68%

• Understanding the cellular mechanics of coral bleaching

  Hu, K.

  OTHER: Foreign Other

  6/1/21 → 5/31/24

  Project: Research project

  • Anthozoa 100%
  • Cnidaria 84%
  • Exocytosis 78%
  • endosidin 2 36%
  • Parasites 29%

• Bioenergetics, Population Genetics, and the Origin of Cellular Features

  Lynch, M.

  Simons Foundation

  9/1/20 → 12/31/24

  Project: Research project

  • bioenergetics 100%
  • eukaryote 91%
  • population genetics 90%
  • natural selection 74%
  • genomics 70%

• Identifying the mechanisms of mechanosensing by the bacterial flagellar motor

  Wadhwa, N.

  HHS: National Institutes of Health (NIH)

  9/1/20 → 11/30/25

  Project: Research project

  • Bacteria 100%
  • Biofilms 90%
  • bis(3',5')-cyclic diguanylic acid 57%
  • Flagella 22%
  • Molecular Imaging 21%

• EDGE CT: Development of a Molecular Toolkit for Integrative Organismal Research in the Microcrustacean Daphnia pulex

  Lynch, M.

  National Science Foundation (NSF)

  12/1/19 → 11/30/24

  Project: Research project

  • Daphnia pulex 100%
  • Daphnia 71%
  • ecology 26%
  • genetic transformation 26%
  • Biological Sciences 26%

• A quantitative examination of cellular mechanisms that modulate the impacts of genetic variation

  Geiler-Samerotte, K.

  HHS: National Institutes of Health (NIH)

  9/1/19 → 6/30/24

  Project: Research project

  • Genetic Variation 100%
  • Mutation 57%
  • Genetic Background 22%
  • Gene Regulatory Networks 11%
  • Yeasts 8%

• Dimensions US-China Global Patterns of Biodiversity in the Ancient Ciliate Paramecium

  Lynch, M.

  National Science Foundation (NSF)

  9/1/19 → 8/31/24

  Project: Research project

  • Paramecium 100%
  • Ciliophora 83%
  • biodiversity 63%
  • China 50%
  • population genetics 34%

• Causes and Population-Genetic Consequences of Molecular Variation

  Lynch, M.

  HHS-NIH: National Institute of General Medical Sciences (NIGMS)

  1/1/18 → 4/30/24

  Project: Research project

  • population genetics 100%
  • natural selection 63%
  • Daphnia pulex 62%
  • mutation 46%
  • human health 41%
• Finished

  Cytoskeletal machinery driving invasion by the human pathogen, Toxoplasma gondii.

  Hu, K.

  HHS: National Institutes of Health (NIH)

  1/1/21 → 12/31/23

  Project: Research project

  • Toxoplasma gondii 100%
  • animal pathogens 93%
  • parasites 29%
  • host cell invasion 22%
  • immunocompromised population 21%

• How does a bacterium become part of its host cell? The cell biology of symbiosis.

  McCutcheon, J.

  Gordon and Betty Moore Foundation

  11/24/20 → 2/1/22

  Project: Research project

  • biology 100%

• CAREER: The origins of genome complexity in an insect-bacteriaendosymbiosis

  McCutcheon, J.

  National Science Foundation (NSF)

  11/15/20 → 1/31/23

  Project: Research project

  • mitochondria 100%
  • insects 82%
  • endosymbionts 75%
  • genome 72%
  • Magicicada 33%

• Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary TractInfection

  Lynch, M.

  Mayo Clinic Arizona

  2/15/20 → 3/23/21

  Project: Research project

  • microbiome 100%
  • menopause 99%
  • therapeutics 80%
  • urinary tract diseases 79%
  • estrogens 41%

• Understanding the Role of Transcription Errors in Aging and Disease

  Lynch, M.

  HHS: National Institutes of Health (NIH)

  7/1/19 → 2/28/22

  Project: Research project

  • RNA 100%
  • Yeasts 49%
  • Gene Library 43%
  • Names 39%
  • DNA Sequence Analysis 20%

• Prokaryotic Genomic Instability

  Lynch, M.

  DOD: Army

  1/1/18 → 11/30/18

  Project: Research project

  • mutation accumulation 100%
  • genetic instability 98%
  • mutation rate 52%
  • SOS response (genetics) 34%
  • antibiotics 20%

• Methods for the Analysis of Population-Genomic Data

  Lynch, M.

  NSF: Directorate for Biological Sciences (BIO)

  1/1/18 → 1/31/19

  Project: Research project

  • Demography 100%
  • Genomics 64%
  • Websites 52%

• Evolution of the Transcriptional Vocabulary: the Paramecium Aurelia Complex

  Lynch, M.

  National Science Foundation (NSF)

  1/1/18 → 7/31/21

  Project: Research project

  • Paramecium 100%
  • transcription factors 61%
  • Caudata 40%
  • binding sites 40%
  • promoter regions 30%

• Understanding the Role of Transcription Errors in Aging and Disease

  Lynch, M.

  HHS: National Institutes of Health (NIH)

  1/1/18 → 8/16/18

  Project: Research project

  • RNA 100%
  • Yeasts 49%
  • Gene Library 43%
  • Names 39%
  • Tandem Repeat Sequences 26%

• Genetic and Environmental Determinants of Population Structure During Escherichia Coli Experimental Evolution

  LaBaer, J. & Lynch, M.

  HHS-NIH: National Institute of General Medical Sciences (NIGMS)

  8/1/17 → 8/27/19

  Project: Research project

  • population structure 100%
  • Escherichia coli 73%
  • microorganisms 25%
  • fimbriae 22%
  • effective population size 21%

• Evolution of the Transcriptional Vocabulary: The Paramecium Aurelia Complex

  LaBaer, J.

  National Science Foundation (NSF)

  8/1/17 → 12/31/17

  Project: Research project

  • Paramecium 100%
  • genes 24%
  • gene duplication 21%
  • transcription factors 20%
  • duplicate genes 18%

• Mechanisms of Prokaryotic Evolution

  Lynch, M.

  US Department of Defense (DOD)

  8/1/17 → 8/14/23

  Project: Research project

  • mutation rate 100%
  • population size 84%
  • mutation 54%
  • bacteria 44%
  • metabolism 33%

• Methods for the Analysis of Population-Genomic Data

  LaBaer, J.

  National Science Foundation (NSF)

  8/1/17 → 12/31/17

  Project: Research project

  • Genomics 100%
  • Population Genetics 35%
  • Open access 31%
  • Graphical user interfaces 24%
  • Interfaces (computer) 22%

• The Rate and Molecular Spectrum of Spontaneous Mutations

  LaBaer, J.

  HHS: National Institutes of Health (NIH)

  8/1/17 → 12/31/17

  Project: Research project

  • DNA-Directed RNA Polymerases 100%
  • Plant RNA 74%
  • Arabidopsis 58%
  • Mutation 50%
  • Mutation Rate 47%