BI: Inflammation and Cancer, Biodesign Institute Center for (IC)

Research Output 2013 2019

2019

Cancer cell evolution through the ages

Maley, C. & Shibata, D., Aug 2 2019, In : Science (New York, N.Y.). 365, 6452, p. 440-441 2 p.

Research output: Contribution to journalComment/debate

Clonal Evolution
Advanced Glycosylation End Products
Neoplasms
2018
17 Citations (Scopus)

Adaptive global innovative learning environment for glioblastoma: GBM AGILE

GBM AGILE Network, Feb 15 2018, In : Clinical Cancer Research. 24, 4, p. 737-743 7 p.

Research output: Contribution to journalReview article

Glioblastoma
Learning
Biomarkers
Therapeutics
Random Allocation
4 Citations (Scopus)

Cancer initiation and progression within the cancer microenvironment

Leong, S. P., Aktipis, C. A. & Maley, C., Jul 11 2018, (Accepted/In press) In : Clinical and Experimental Metastasis. p. 1-7 7 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Neoplasms
Growth
Biological Phenomena
Melanoma
8 Citations (Scopus)

Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels

Martinez, P., Mallo, D., Paulson, T. G., Li, X., Sanchez, C. A., Reid, B. J., Graham, T. A., Kuhner, M. K. & Maley, C., Dec 1 2018, In : Nature Communications. 9, 1, 794.

Research output: Contribution to journalArticle

esophagus
Barrett Esophagus
Biopsy
progressions
Clocks

Improving classification with forced labeling of other related classes: Application to prediction of upstaged ductal carcinoma in situ using mammographic features

Hou, R., Shi, B., Grimm, L. J., Mazurowski, M. A., Marks, J. R., King, L. M., Maley, C., Shelley Hwang, E. & Lo, J. Y., Jan 1 2018, Medical Imaging 2018: Computer-Aided Diagnosis. SPIE, Vol. 10575. 105750R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carcinoma, Intraductal, Noninfiltrating
Biopsy
Labeling
marking
cancer

Learning better deep features for the prediction of occult invasive disease in ductal carcinoma in situ through transfer learning

Shi, B., Hou, R., Mazurowski, M. A., Grimm, L. J., Ren, Y., Marks, J. R., King, L. M., Maley, C., Hwang, E. S. & Lo, J. Y., Jan 1 2018, Medical Imaging 2018: Computer-Aided Diagnosis. SPIE, Vol. 10575. 105752R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carcinoma, Intraductal, Noninfiltrating
learning
Biopsy
cancer
Learning
3 Citations (Scopus)

Modeling the subclonal evolution of cancer cell populations

Chowell, D., Napier, J., Gupta, R., Anderson, K., Maley, C. & Wilson Sayres, M., Feb 1 2018, In : Cancer Research. 78, 3, p. 830-839 10 p.

Research output: Contribution to journalArticle

Population
Neoplasms
Clone Cells
Genetic Drift
Mutation
12 Citations (Scopus)

Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features

Shi, B., Grimm, L. J., Mazurowski, M. A., Baker, J. A., Marks, J. R., King, L. M., Maley, C., Hwang, E. S. & Lo, J. Y., Jan 1 2018, (Accepted/In press) In : Journal of the American College of Radiology.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Learning
ROC Curve
Confidence Intervals
Large-Core Needle Biopsy
4 Citations (Scopus)

The spatiotemporal evolution of lymph node spread in early breast cancer

Barry, P., Vatsiou, A., Spiteri, I., Nichol, D., Cresswell, G. D., Acar, A., Trahearn, N., Hrebien, S., Garcia-Murillas, I., Chkhaidze, K., Ermini, L., Huntingford, I. S., Cottom, H., Zabaglo, L., Koelble, K., Khalique, S., Rusby, J. E., Muscara, F., Dowsett, M., Maley, C. & 5 others, Natrajan, R., Yuan, Y., Schiavon, G., Turner, N. & Sottoriva, A., Oct 1 2018, In : Clinical Cancer Research. 24, 19, p. 4763-4770 8 p.

Research output: Contribution to journalArticle

Lymph Nodes
Breast Neoplasms
DNA
Neoplasms
Neoplasm Metastasis
2017
5 Citations (Scopus)

Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?

Shi, B., Grimm, L. J., Mazurowski, M. A., Baker, J. A., Marks, J. R., King, L. M., Maley, C., Hwang, E. S. & Lo, J. Y., Sep 1 2017, In : Academic Radiology. 24, 9, p. 1139-1147 9 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
ROC Curve
Information Systems
Area Under Curve
Breast

Can upstaging of ductal carcinoma in situ be predicted at biopsy by histologic and mammographic features?

Shi, B., Grimm, L. J., Mazurowski, M. A., Marks, J. R., King, L. M., Maley, C., Hwang, E. S. & Lo, J. Y., 2017, Medical Imaging 2017: Computer-Aided Diagnosis. SPIE, Vol. 10134. 101342X

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carcinoma, Intraductal, Noninfiltrating
Biopsy
cancer
Screening
Needles
7 Citations (Scopus)

Carbon dating cancer: Defining the chronology of metastatic progression in colorectal cancer

Lote, H., Spiteri, I., Ermini, L., Vatsiou, A., Roy, A., McDonald, A., Maka, N., Balsitis, M., Bose, N., Simbolo, M., Mafficini, A., Lampis, A., Hahne, J. C., Trevisani, F., Eltahir, Z., Mentrasti, G., Findlay, C., Kalkman, E. A. J., Punta, M., Werner, B. & 10 others, Lise, S., Aktipis, C. A., Maley, C., Greaves, M., Braconi, C., White, J., Fassan, M., Scarpa, A., Sottoriva, A. & Valeri, N., Jun 1 2017, In : Annals of Oncology. 28, 6, p. 1243-1249 7 p., mdx074.

Research output: Contribution to journalArticle

Radiometric Dating
Chronology
Colorectal Neoplasms
Neoplasms
Neoplasm Metastasis
55 Citations (Scopus)

Classifying the evolutionary and ecological features of neoplasms

Maley, C., Aktipis, C. A., Graham, T. A., Sottoriva, A., Boddy, A. M., Janiszewska, M., Silva, A. S., Gerlinger, M., Yuan, Y., Pienta, K. J., Anderson, K., Gatenby, R., Swanton, C., Posada, D., Wu, C. I., Schiffman, J. D., Hwang, E. S., Polyak, K., Anderson, A. R. A., Brown, J. S. & 2 others, Greaves, M. & Shibata, D., Oct 1 2017, In : Nature Reviews Cancer. 17, 10, p. 605-619 15 p.

Research output: Contribution to journalReview article

Neoplasms
Ecology
Precision Medicine
Molecular Evolution
Epigenomics
4 Citations (Scopus)
innovation
Innovation
cells
Microbiota
organisms
23 Citations (Scopus)

Genomic instability in cancer: Teetering on the limit of tolerance

Andor, N., Maley, C. & Ji, H. P., May 1 2017, In : Cancer Research. 77, 9, p. 2179-2185 7 p.

Research output: Contribution to journalArticle

Genomic Instability
Neoplasms
Clone Cells
Genome
Genetic Heterogeneity
10 Citations (Scopus)

Natural selection in cancer biology: From molecular snowflakes to trait hallmarks

Fortunato, A., Boddy, A., Mallo, D., Aktipis, C. A., Maley, C. & Pepper, J. W., Feb 1 2017, In : Cold Spring Harbor perspectives in medicine. 7, 2, a029652.

Research output: Contribution to journalArticle

Genetic Selection
Molecular Biology
Neoplasms
Pathology
Clonal Evolution
7 Citations (Scopus)

Peto's Paradox: How has evolution solved the problem of cancer prevention?

Tollis, M., Boddy, A. M. & Maley, C., Jul 13 2017, In : BMC Biology. 15, 1, 60.

Research output: Contribution to journalComment/debate

cancer
Animals
neoplasms
Neoplasms
Cell Count
2 Citations (Scopus)

Prediction of occult invasive disease in ductal carcinoma in situ using computer-extracted mammographic features

Shi, B., Grimm, L. J., Mazurowski, M. A., Marks, J. R., King, L. M., Maley, C., Hwang, E. S. & Lo, J. Y., 2017, Medical Imaging 2017: Computer-Aided Diagnosis. SPIE, Vol. 10134. 101341I

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Carcinoma, Intraductal, Noninfiltrating
cancer
predictions
Calcinosis
Mammography
2016
34 Citations (Scopus)

Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus

Martinez, P., Timmer, M. R., Lau, C. T., Calpe, S., Sancho-Serra, M. D. C., Straub, D., Baker, A. M., Meijer, S. L., Kate, F. J. W. T., Mallant-Hent, R. C., Naber, A. H. J., Van Oijen, A. H. A. M., Baak, L. C., Scholten, P., Böhmer, C. J. M., Fockens, P., Bergman, J. J. G. H. M., Maley, C., Graham, T. A. & Krishnadath, K. K., Aug 19 2016, In : Nature Communications. 7, 12158.

Research output: Contribution to journalArticle

esophagus
Barrett Esophagus
cancer
Cytology
surveillance
1 Citation (Scopus)

In reply

Schiffman, J. D., Schmitt, D. L. & Maley, C., Apr 26 2016, In : JAMA - Journal of the American Medical Association. 315, 16, p. 1790-1791 2 p.

Research output: Contribution to journalLetter

Biological Evolution
Disease Resistance
DNA Damage
Neoplasms
5 Citations (Scopus)

Krüppel-like factor 12 promotes colorectal cancer growth through early growth response protein 1

Kim, S. H., Park, Y. Y., Cho, S. N., Margalit, O., Wang, D. & Dubois, R. N., Jul 1 2016, In : PLoS One. 11, 7, e0159899.

Research output: Contribution to journalArticle

Early Growth Response Protein 1
colorectal neoplasms
Colorectal Neoplasms
stomach neoplasms
Growth
214 Citations (Scopus)

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

Andor, N., Graham, T. A., Jansen, M., Xia, L. C., Aktipis, C. A., Petritsch, C., Ji, H. P. & Maley, C., Jan 1 2016, In : Nature Medicine. 22, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

Tumors
Clone Cells
Neoplasms
Genes
Genomic Instability
28 Citations (Scopus)

The Role of Prostaglandin E2 in Tumor-Associated Immunosuppression

Wang, D. & DuBois, R. N., Jan 1 2016, In : Trends in Molecular Medicine. 22, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Dinoprostone
Immunosuppression
Dolphins
Immunologic Monitoring
Neoplasms
1 Citation (Scopus)

When (distant) relatives stay too long: Implications for cancer medicine

Chowell, D., Boddy, A. M., Mallo, D., Tollis, M. & Maley, C., Feb 24 2016, In : Genome Biology. 17, 1, 34.

Research output: Contribution to journalArticle

Medulloblastoma
relapse
Human Genome
medicine
clone
2015
16 Citations (Scopus)

An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer

Maley, C., Koelble, K., Natrajan, R., Aktipis, C. A. & Yuan, Y., Sep 22 2015, In : Breast Cancer Research. 17, 1, 131.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Histology
Biota
Tumor Microenvironment
19 Citations (Scopus)

Assessment of esophageal adenocarcinoma risk using somatic chromosome alterations in longitudinal samples in Barrett's esophagus

Li, X., Paulson, T. G., Galipeau, P. C., Sanchez, C. A., Liu, K., Kuhner, M. K., Maley, C., Self, S. G., Vaughan, T. L., Reid, B. J. & Blount, P. L., Sep 1 2015, In : Cancer Prevention Research. 8, 9, p. 845-856 12 p.

Research output: Contribution to journalArticle

Barrett Esophagus
Adenocarcinoma
Chromosomes
Neoplasms
Biopsy
92 Citations (Scopus)

Cancer across the tree of life: Cooperation and cheating in multicellularity

Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. & Wilkinson, G. S., Jul 19 2015, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 370, 1673

Research output: Contribution to journalArticle

cancer
Personnel
neoplasms
Deregulation
Biomarkers
80 Citations (Scopus)

Immunosuppression associated with chronic inflammation in the tumor microenvironment

Wang, D. & Du Bois, R. N., Aug 16 2015, In : Carcinogenesis. 36, 10, p. 1085-1093 9 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
Immunosuppression
Inflammation
Neoplasms
17 Citations (Scopus)

Peto’s paradox and the promise of comparative oncology

Nunney, L., Maley, C., Breen, M., Hochberg, M. E. & Schiffman, J. D., Jul 19 2015, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 370, 1673

Research output: Contribution to journalArticle

Oncology
cancer
Tissue
Epidemiology
neoplasms
118 Citations (Scopus)

Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA Damage in Humans

Abegglen, L. M., Caulin, A. F., Chan, A., Lee, K., Robinson, R., Campbell, M. S., Kiso, W. K., Schmitt, D. L., Waddell, P. J., Bhaskara, S., Jensen, S. T., Maley, C. & Schiffman, J. D., Nov 3 2015, In : JAMA - Journal of the American Medical Association. 314, 17, p. 1850-1860 11 p.

Research output: Contribution to journalArticle

DNA Damage
Li-Fraumeni Syndrome
Neoplasms
Body Size
Lymphocytes
82 Citations (Scopus)

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Wang, D., Fu, L., Sun, H., Guo, L. & Dubois, R. N., Dec 1 2015, In : Gastroenterology. 149, 7, p. 1884-1895e4

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Dinoprostone
Colorectal Neoplasms
Neoplasm Metastasis
Celecoxib
68 Citations (Scopus)

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia

Paguirigan, A. L., Smith, J., Meshinchi, S., Carroll, M., Maley, C. & Radich, J. P., Apr 1 2015, In : Science Translational Medicine. 7, 281, 281re2.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Clonal Evolution
Mutation
Neoplasms
Recurrence
27 Citations (Scopus)

Solutions to peto’s paradox revealed by mathematical modelling and cross-species cancer gene analysis

Caulin, A. F., Graham, T. A., Wang, L. S. & Maley, C., Jul 19 2015, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 370, 1673

Research output: Contribution to journalArticle

Neoplasm Genes
cancer
mathematical models
Genes
Whales
2014
11 Citations (Scopus)

CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models

Kim, S. H., Margalit, O., Katoh, H., Wang, D., Wu, H., Xia, D., Holla, V. R., Yang, P. & Dubois, R. N., Dec 1 2014, In : Investigational New Drugs. 32, 6, p. 1105-1112 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Adenoma
Colorectal Neoplasms
Growth
Anti-Inflammatory Agents
32 Citations (Scopus)

Peroxisome proliferator-activated receptor ä promotes colonic inflammation and tumor growth

Wang, D., Fu, L., Ning, W., Guo, L., Sun, X., Dey, S. K., Chaturvedi, R., Wilson, K. T. & DuBois, R. N., May 13 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 19, p. 7084-7089 6 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Prostaglandins E
Inflammation
Colitis
Growth
2013
49 Citations (Scopus)

An inflammatory mediator, prostaglandin e2, in colorectal cancer

Wang, D. & Dubois, R. N., Nov 2013, In : Cancer Journal (United States). 19, 6, p. 502-510 9 p.

Research output: Contribution to journalArticle

Dinoprostone
Colorectal Neoplasms
Dietary Fats
Prostaglandin-Endoperoxide Synthases
Inflammation
180 Citations (Scopus)

CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis

Katoh, H., Wang, D., Daikoku, T., Sun, H., Dey, S. K. & DuBois, R. N., Nov 11 2013, In : Cancer Cell. 24, 5, p. 631-644 14 p.

Research output: Contribution to journalArticle

Colitis
Carcinogenesis
Neoplasms
Mucous Membrane
Inflammation
7 Citations (Scopus)

HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways

Kim, S. H., Wang, D., Park, Y. Y., Katoh, H., Margalit, O., Sheffer, M., Wu, H., Holla, V. R., Lee, J. S. & DuBois, R. N., Dec 1 2013, In : Cancer Letters. 341, 2, p. 159-165 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Genes
Neoplasms
Transcription Factor AP-1
Growth
26 Citations (Scopus)

Urinary PGE-M: A promising cancer biomarker

Wang, D. & DuBois, R. N., Jun 2013, In : Cancer Prevention Research. 6, 6, p. 507-510 4 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
Neoplasms
Biomarkers
Breast Neoplasms
Inflammation