BI: Bioenergetics, Center for (BE)

Research Output 2006 2019

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18 Citations (Scopus)

A dedicated type II NADPH dehydrogenase performs the penultimate step in the biosynthesis of vitamin K<inf>1</inf> in synechocystis and arabidopsis

Fatihi, A., Latimer, S., Schmollinger, S., Block, A., Dussault, P. H., Vermaas, W., Merchant, S. S. & Basset, G. J., Jun 1 2015, In : Plant Cell. 27, 6, p. 1730-1741 12 p.

Research output: Contribution to journalArticle

Vitamin K 1
Synechocystis
phylloquinone
NADPH Dehydrogenase
vitamin K
13 Citations (Scopus)

An acetate prodrug of a pyridinol-based vitamin e analogue

Khdour, O., Lu, J. & Hecht, S., Nov 2011, In : Pharmaceutical Research. 28, 11, p. 2896-2909 14 p.

Research output: Contribution to journalArticle

Prodrugs
Vitamins
Acetates
Mitochondria
Oxidative stress
17 Citations (Scopus)

Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection

Arce, P. M., Goldschmidt, R., Khdour, O., Madathil, M. M., Jaruvangsanti, J., Dey, S., Fash, D. M., Armstrong, J. S. & Hecht, S., Sep 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 17, p. 5188-5201 14 p.

Research output: Contribution to journalArticle

Cytoprotection
Antioxidants
Lymphocytes
Neuroprotective Agents
Electron Transport
2 Citations (Scopus)

A new strategy for the synthesis of bisaminoacylated tRNAs

Nangreave, R. C., Dedkova, L., Chen, S. & Hecht, S., Sep 16 2011, In : Organic Letters. 13, 18, p. 4906-4909 4 p.

Research output: Contribution to journalArticle

Transfer RNA
amino acids
protein synthesis
synthesis
condensation
11 Citations (Scopus)

An optimized pyrimidinol multifunctional radical quencher

Khdour, O., Arce, P. M., Roy, B. & Hecht, S., Aug 8 2013, In : ACS Medicinal Chemistry Letters. 4, 8, p. 724-729 6 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
coenzyme Q10
Oxidative stress
Lymphocytes
Antioxidants
9 Citations (Scopus)

A novel technique for synthesizing MgB2 thin films with high upper critical fields

Shen, Y., Gandikota, R., Singh, R., Hunte, F. L., Jaroszynski, J., Larbalestier, D. C., Rowell, J. M. & Newman, N., Aug 1 2008, In : Superconductor Science and Technology. 21, 8, 085009.

Research output: Contribution to journalArticle

Magnesium
magnesium
Thin films
Boron
Aluminum Oxide
14 Citations (Scopus)

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

Tang, C., Paul, A., Alam, M. P., Roy, B., Wilson, W. D. & Hecht, S., Sep 4 2014, In : Journal of the American Chemical Society. 136, 39, p. 13715-13726 12 p.

Research output: Contribution to journalArticle

DNA sequences
Bleomycin
DNA
DNA Cleavage
Gene Library
23 Citations (Scopus)

A strategy for suppressing redox stress within mitochondria

Arce, P. M., Khdour, O., Goldschmidt, R., Armstrong, J. S. & Hecht, S., Aug 11 2011, In : ACS Medicinal Chemistry Letters. 2, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

Mitochondria
Oxidative stress
Oxidation-Reduction
Oxidative Stress
Friedreich Ataxia
3 Citations (Scopus)

A structurally simplified analogue of geldanamycin exhibits neuroprotective activity

Madathil, M. M., Khdour, O., Jaruvangsanti, J. & Hecht, S., Oct 10 2013, In : ACS Medicinal Chemistry Letters. 4, 10, p. 953-957 5 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Lymphocytes
Cytoprotection
Mitochondrial Membrane Potential
Cytotoxicity
2 Citations (Scopus)

Better Resolution of High-Spin Cobalt Hyperfine at Low Frequency: Co-Doped Ba(Zn1/3Ta2/3)O₃ as a Model Complex

Antholine, W. E., Zhang, S., Gonzales, J. & Newman, N., Nov 9 2018, In : International Journal of Molecular Sciences. 19, 11

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Cobalt
Paramagnetic resonance
electron paramagnetic resonance
cobalt
16 Citations (Scopus)

Beyond Ebola: Lessons to mitigate future pandemics

Castillo-Chavez, C., Curtiss, R., Daszak, P., Levin, S. A., Patterson-Lomba, O., Perrings, C., Poste, G. & Towers, S., Jul 1 2015, In : The Lancet Global Health. 3, 7, p. e354-e355

Research output: Contribution to journalArticle

Ebola Hemorrhagic Fever
Ebolavirus
Communicable Disease Control
Pandemics
Global Health
33 Citations (Scopus)

Biospecimens, biomarkers, and burgeoning data: The imperative for more rigorous research standards

Poste, G., Dec 2012, In : Trends in Molecular Medicine. 18, 12, p. 717-722 6 p.

Research output: Contribution to journalArticle

Biomarkers
Research
Exome
Specimen Handling
Systems Analysis
1 Citation (Scopus)

Breaking down silos for improved biomarker development: An interview with George Poste

Poste, G., Nov 1 2015, In : Expert Review of Molecular Diagnostics. 15, 8, p. 975-978 4 p.

Research output: Contribution to journalArticle

Exosomes
Biomarkers
Interviews
339 Citations (Scopus)

Bring on the biomarkers

Poste, G., Jan 13 2011, In : Nature. 469, 7329, p. 156-157 2 p.

Research output: Contribution to journalArticle

Biological Specimen Banks
Specimen Handling
Precision Medicine
Pharmacogenetics
Medical Genetics
63 Citations (Scopus)

Calothrixins, a new class of human DNA topoisomerase i poisons

Khan, Q. A., Lu, J. & Hecht, S., Mar 27 2009, In : Journal of Natural Products. 72, 3, p. 438-442 5 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Poisons
Cell Cycle
Cells
Camptothecin
37 Citations (Scopus)

Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates

Chapuis, J., Schmaltz, R. M., Tsosie, K. S., Belohlavek, M. & Hecht, S., Feb 25 2009, In : Journal of the American Chemical Society. 131, 7, p. 2438-2439 2 p.

Research output: Contribution to journalArticle

Vibrissae
Microbubbles
Bleomycin
Physical vapor deposition
Carbohydrates
3 Citations (Scopus)

Catalytic conversion of cyanobacteria-derived fatty acids to alkanes for biorenewable synthetic paraffinic kerosene

Schulz, T. C., Oelschlager, M., Thompson, S. T., Vermaas, W., Nielsen, D. & Lamb, H. H., Jan 1 2018, In : Sustainable Energy and Fuels. 2, 4, p. 882-893 12 p.

Research output: Contribution to journalArticle

Open Access
Kerosene
Fatty acids
Paraffins
Purification
Acids
3 Citations (Scopus)

Cd13-xinySb10 (x≈ 2.7, y≈1.5): An interstitial-free variant of thermoelectric ß-Zn 4Sb3

Tengå, A., Lidin, S., Belieres, J. P., Newman, N., Wu, Y. & Häussermann, U., Jul 6 2009, In : Chemistry - A European Journal. 15, 27, p. 6704-6710 7 p.

Research output: Contribution to journalArticle

Polymorphism
Cadmium
Temperature
Intermetallics
Thermal conductivity
19 Citations (Scopus)

Characterization of bleomycin cleavage sites in strongly bound hairpin DNAs

Giroux, R. A. & Hecht, S., Dec 1 2010, In : Journal of the American Chemical Society. 132, 47, p. 16987-16996 10 p.

Research output: Contribution to journalArticle

Bleomycin
DNA
Alkalies
Degradation
DNA Cleavage
15 Citations (Scopus)

Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library

Segerman, Z. J., Roy, B. & Hecht, S., Aug 6 2013, In : Biochemistry. 52, 31, p. 5315-5327 13 p.

Research output: Contribution to journalArticle

Bleomycin
Gene Library
DNA
DNA Cleavage
DNA Damage
7 Citations (Scopus)

Characterization of Josephson and quasi-particle currents in MgB 2/MgB2 and Pb/Pb contact junctions

Shen, Y., Singh, R., Sanghavi, S., Wei, Y., Chamberlin, R., Moeckly, B. H., Rowell, J. M. & Newman, N., 2010, In : Superconductor Science and Technology. 23, 7, 075003.

Research output: Contribution to journalArticle

elementary excitations
Oxides
electric contacts
Electrodes
Electric properties

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Bandyopadhyay, I., Chowdhury, S. R., Visavadiya, N. P., Hecht, S. & Khdour, O., Oct 1 2018, In : Data in Brief. 20, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Methylene Blue
frataxin
16 Citations (Scopus)
Cytostatic Agents
Nucleophiles
Quinones
Protonation
Hydrogen

Clean to dirty limit and T c suppression in NdFeAsO0.7F0.3 studied by H c2 analysis

Pallecchi, I., Tarantini, C., Shen, Y., Singh, R., Newman, N., Cheng, P., Jia, Y., Wen, H. H. & Putti, M., Feb 14 2018, In : Superconductor Science and Technology. 31, 3, 034007.

Research output: Contribution to journalArticle

retarding
Irradiation
slopes
Superconducting materials
irradiation
4 Citations (Scopus)

ClpB1 overproduction in Synechocystis sp. strain PCC 6803 increases tolerance to rapid heat shock

Gonzalez-Esquer, C. R. & Vermaas, W., 2013, In : Applied and Environmental Microbiology. 79, 20, p. 6220-6227 8 p.

Research output: Contribution to journalArticle

Synechocystis
heat shock
Heat-Shock Proteins
heat shock proteins
cell viability
29 Citations (Scopus)

Comparative study of the thermoelectric properties of amorphous Zn 41Sb 59 and crystalline Zn 4Sb 3

Wu, Y., Nylén, J., Naseyowma, C., Newman, N., Francisco, J. G. G. & Häussermann, U., Jan 13 2009, In : Chemistry of Materials. 21, 1, p. 151-155 5 p.

Research output: Contribution to journalArticle

Crystalline materials
Thermoelectric power
Thermal conductivity
Temperature
Crystal lattices
8 Citations (Scopus)

Composition modulations in Al0.4 Ga0.6 N layers grown by molecular beam epitaxy

Wise, A., Nandivada, R., Strawbridge, B., Carpenter, R., Newman, N. & Mahajan, S., 2008, In : Applied Physics Letters. 92, 26, 261914.

Research output: Contribution to journalArticle

molecular beam epitaxy
modulation
composite materials
wetting
sapphire
20 Citations (Scopus)

Concise synthesis of bicyclic pyridinol antioxidants

Lu, J., Cai, X. & Hecht, S., Nov 19 2010, In : Organic Letters. 12, 22, p. 5189-5191 3 p.

Research output: Contribution to journalArticle

antioxidants
Antioxidants
tocopherol
Lactams
acetals
8 Citations (Scopus)

Converging and emerging threats to health security

Raina Macintyre, C., Engells, T. E., Scotch, M., Heslop, D. J., Gumel, A., Poste, G., Chen, X., Herche, W., Steinhöfel, K., Lim, S. & Broom, A., Nov 27 2017, (Accepted/In press) In : Environment Systems and Decisions. p. 1-10 10 p.

Research output: Contribution to journalArticle

biological weapon
regulatory framework
Cold War
medicine
health care
10 Citations (Scopus)

Criteria for improving the properties of ZnGeAs2 solar cells

Peshek, T. J., Zhang, L., Singh, R., Tang, Z., Vahidi, M., To, B., Coutts, T. J., Gessert, T. A., Newman, N. & Van Schilfgaarde, M., Aug 2013, In : Progress in Photovoltaics: Research and Applications. 21, 5, p. 906-917 12 p.

Research output: Contribution to journalArticle

Solar cells
solar cells
absorbers (materials)
Hole mobility
Borosilicate glass
26 Citations (Scopus)

Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction

Talukder, P., Chen, S., Roy, B., Yakovchuk, P., Spiering, M. M., Alam, M. P., Madathil, M. M., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Dec 29 2015, In : Biochemistry. 54, 51, p. 7457-7469 13 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
DNA Polymerase I
Heterogeneous-Nuclear Ribonucleoprotein L
Energy Transfer
Energy transfer
13 Citations (Scopus)

Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases

Alam, M. P., Khdour, O., Arce, P. M., Chen, Y., Roy, B., Johnson, W. G., Dey, S. & Hecht, S., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

Mitochondrial Diseases
Neurodegenerative Diseases
Antioxidants
Mitochondrial Membrane Potential
Liver Microsomes
24 Citations (Scopus)

Defect energy levels and electronic behavior of Ni-, Co-, and As-doped synthetic pyrite (FeS 2)

Lehner, S. W., Newman, N., Van Schilfgaarde, M., Bandyopadhyay, S., Savage, K. & Buseck, P. R., Apr 15 2012, In : Journal of Applied Physics. 111, 8, 083717.

Research output: Contribution to journalArticle

pyrites
energy levels
conduction bands
defects
electronics
4 Citations (Scopus)

Deglycobleomycin A6 analogues modified in the methylvalerate moiety

Cai, X., Zaleski, P. A., Cagir, A. & Hecht, S., Jun 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 12, p. 3831-3844 14 p.

Research output: Contribution to journalArticle

DNA Cleavage
Bleomycin
DNA
Valerates
Superhelical DNA
9 Citations (Scopus)

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

Bernatchez, J. A., Paul, R., Tchesnokov, E. P., Ngure, M., Beilhartz, G. L., Berghuis, A. M., Lavoie, R., Li, L., Auger, A., Melnyk, R. A., Grobler, J. A., Miller, M. D., Hazuda, D. J., Hecht, S. & Götte, M., Jan 16 2015, In : Journal of Biological Chemistry. 290, 3, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

HIV-1
Foscarnet
Derivatives
RNA-Directed DNA Polymerase
Metal ions
13 Citations (Scopus)

Design, synthesis, and evaluation of an α-tocopherol analogue as a mitochondrial antioxidant

Lu, J., Khdour, O., Armstrong, J. S. & Hecht, S., Nov 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 21, p. 7628-7638 11 p.

Research output: Contribution to journalArticle

Tocopherols
Antioxidants
Trifluoroacetic Acid
Mitochondrial Membranes
Cultured Cells
19 Citations (Scopus)

Design and expression of a short peptide as an HIV detection probe

Lines, J. A., Yu, Z., Dedkova, L. & Chen, S., Jan 3 2014, In : Biochemical and Biophysical Research Communications. 443, 1, p. 308-312 5 p.

Research output: Contribution to journalArticle

HIV
Peptides
Proteins
Escherichia coli
HIV Infections
18 Citations (Scopus)

Design of a cyclopropyl quinone methide reductive alkylating agent. 2

Khdour, O., Ouyang, A. & Skibo, E. B., Aug 1 2006, In : Journal of Organic Chemistry. 71, 16, p. 5855-5863 9 p.

Research output: Contribution to journalArticle

Alkylating Agents
Labels
Carbon
indole
quinone methide
40 Citations (Scopus)

Detection of dihydrofolate reductase conformational change by fret using two fluorescent amino acids

Chen, S., Fahmi, N. E., Wang, L., Bhattacharya, C., Benkovic, S. J. & Hecht, S., Sep 4 2013, In : Journal of the American Chemical Society. 135, 35, p. 12924-12927 4 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Amino acids
Amino Acids
Fluorophores
Energy Transfer

DNA-affibody nanoparticle delivery system for cisplatin-based breast cancer chemotherapy

Zhang, C., Zhang, H. L., Han, M. N., Yang, X. L., Pei, C. H., Xu, Z. D., Du, J., Li, W. & Chen, S., Jan 1 2019, In : RSC Advances. 9, 4, p. 1982-1989 8 p.

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Cisplatin
DNA
Nanoparticles
Toxicity
11 Citations (Scopus)

DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2

Zhang, Y., Jiang, S., Zhang, D., Bai, X., Hecht, S. & Chen, S., 2017, In : Chemical Communications. 53, 3, p. 573-576 4 p.

Research output: Contribution to journalArticle

DNA
Cells
Nanoparticles
Doxorubicin
Molecules
8 Citations (Scopus)

DNA methylation reduces binding and cleavage by bleomycin

Roy, B., Tang, C., Alam, M. P. & Hecht, S., Sep 30 2014, In : Biochemistry. 53, 38, p. 6103-6112 10 p.

Research output: Contribution to journalArticle

Bleomycin
DNA Methylation
DNA Cleavage
Methylation
DNA
76 Citations (Scopus)

Does oxidative stress contribute to the pathology of Friedreich's ataxia? A radical question

Armstrong, J. S., Khdour, O. & Hecht, S., Jul 2010, In : FASEB Journal. 24, 7, p. 2152-2163 12 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Oxidative stress
Pathology
Reactive Oxygen Species
Oxidative Stress
14 Citations (Scopus)

Dynamics of bleomycin interaction with a strongly bound hairpin DNA substrate, and implications for cleavage of the bound DNA

Bozeman, T. C., Nanjunda, R., Tang, C., Liu, Y., Segerman, Z. J., Zaleski, P. A., Wilson, W. D. & Hecht, S., Oct 31 2012, In : Journal of the American Chemical Society. 134, 43, p. 17842-17845 4 p.

Research output: Contribution to journalArticle

DNA Cleavage
Bleomycin
DNA
Substrates
Binding sites

Effect of helium ion irradiation on the tunneling behavior in niobium/aluminum-aluminum oxide/niobium josephson junctions

Zhang, T., Kopas, C., Yu, L., Carpenter, R., Qader, M. A., Huang, M., Singh, R., Mardinly, J., Cantor, R., Rowell, J. M. & Newman, N., 2013, In : IEEE Transactions on Applied Superconductivity. 23, 4, 1101610.

Research output: Contribution to journalArticle

Niobium
Niobium oxide
Helium
Aluminum Oxide
helium ions
54 Citations (Scopus)

Effect of metal doping on the low-temperature structural behavior of thermoelectric β-Zn4Sb3

Nylén, J., Lidin, S., Andersson, M., Liu, H., Newman, N. & Häussermann, U., Sep 2007, In : Journal of Solid State Chemistry. 180, 9, p. 2603-2615 13 p.

Research output: Contribution to journalArticle

Metals
Doping (additives)
Phase transitions
Liquid metals
metals
3 Citations (Scopus)

Effect of non-stoichiometry on the densification, phase purity, microstructure, crystal structure, and dielectric loss of Ba(Co1/3Nb2/3)O3 ceramics

Sayyadi-Shahraki, A., Taheri-Nassaj, E., Gonzales, J., Newman, N. & Kolodiazhnyi, T., Aug 1 2017, In : Journal of the European Ceramic Society. 37, 10, p. 3335-3346 12 p.

Research output: Contribution to journalArticle

Dielectric losses
Densification
Crystal structure
Microstructure
Cations
10 Citations (Scopus)

Effect of oxygen incorporation on normal and superconducting properties of MgB2 films

Singh, R., Shen, Y., Gandikota, R., Carvalho, C., Rowell, J. M. & Newman, N., 2008, In : Applied Physics Letters. 93, 24, 242504.

Research output: Contribution to journalArticle

oxygen
high field magnets
critical current
critical temperature
temperature distribution
3 Citations (Scopus)

Effect of Rb and Cs doping on superconducting properties of MgB2 thin films

Singh, R., Shen, Y., Gandikota, R., Wright, D., Carvalho, C., Rowell, J. M. & Newman, N., Feb 1 2008, In : Superconductor Science and Technology. 21, 2, 025012.

Research output: Contribution to journalArticle

Alkali Metals
Quartz
ampoules
Rutherford backscattering spectroscopy
Alkali metals
14 Citations (Scopus)

Effect of stoichiometry on oxygen incorporation in MgB2 thin films

Singh, R., Shen, Y., Gandikota, R., Rowell, J. M. & Newman, N., Jan 1 2008, In : Superconductor Science and Technology. 21, 1, 015018.

Research output: Contribution to journalArticle

Stoichiometry
stoichiometry
Oxygen
Thin films
oxygen