BI: Bioenergetics, Center for (BE)

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1990

Iron(Ii)-Bleomycin-Mediated Reduction of O2 to Water: An17O Nuclear Magnetic Resonance Study

Barr, J. R., Van Atta, R. B., Natrajan, A., Hecht, S. M., Van Der Marel, G. A. & Van Boom, J. H., Jan 1 1990, In : Journal of the American Chemical Society. 112, 10, p. 4058-4060 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site

Hertzberg, R. P., Busby, R. W., Caranfa, M. J., Holden, K. G., Johnson, R. K., Hecht, S. M. & Kingsbury, W. D., Nov 22 1990, In : Journal of Biological Chemistry. 265, 31, p. 19287-19295 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Carte, B. K., DeBrosse, C., Eggleston, D., Hemling, M., Mentzer, M., Poehland, B., Troupe, N., Westley, J. W. & Hecht, S. M., 1990, In : Tetrahedron. 46, 8, p. 2747-2760 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Metal ion and substrate structure dependence of the processing of tRNA precursors by RNase P and M1 RNA

Surratt, C. K., Carter, B. J., Payne, R. C. & Hecht, S. M., Dec 1 1990, In : Journal of Biological Chemistry. 265, 36, p. 22513-22519 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

On the Chemical Nature of DNA and RNA Modification by a Hemin Model System

Van Atta, R. B., Bernadou, J., Meunier, B. & Hecht, S. M., May 1 1990, In : Biochemistry. 29, 20, p. 4783-4789 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Site-specific cleavage of RNA by Fe(II)·bleomycin

Carter, B. J., De Vroom, E., Long, E. C., Van Der Marel, G. A., Van Boom, J. H. & Hecht, S. M., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 23, p. 9373-9377 5 p.

Research output: Contribution to journalArticle

Open Access
134 Scopus citations

Synthesis of Pyrimidoblamic Acid and Epipyrimidoblamic Acid

Aoyagi, Y., Chorghade, M. S., Padmapriya, A. A., Suguna, H. & Hecht, S. M., Jan 1 1990, In : Journal of Organic Chemistry. 55, 26, p. 6291-6298 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
1991

9-Octadecynoic Acid: A Novel DNA Binding Agent

Berry, D. E., Chan, J. A., MacKenzie, L. & Hecht, S. M., Mar 1 1991, In : Chemical Research in Toxicology. 4, 2, p. 195-198 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

DNA Cleavage by Oxygen Radicals Produced in the Absence of Metal Ions or Light

Nagai, K., Carter, B. J., Xu, J. & Hecht, S. M., Jun 1 1991, In : Journal of the American Chemical Society. 113, 13, p. 5099-5100 2 p.

Research output: Contribution to journalArticle

55 Scopus citations

Metal-catalyzed rna strand scission

Carter, B. J., Holmes, C. E., Van Atta, R. B., Dange, V. & Hecht, S. M., Jan 1 1991, In : Nucleosides and Nucleotides. 10, 1-3, p. 215-227 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Polynucleotide recognition and strand scission by Fe-bleomycin

Carter, B. J., Reddy, K. S. & Hecht, S. M., 1991, In : Tetrahedron. 47, 14-15, p. 2463-2474 12 p.

Research output: Contribution to journalArticle

56 Scopus citations
9 Scopus citations

Site-specific DNA cleavage by antisense oligonucleotides covalently linked to phenazine di-N-oxide

Nagai, K. & Hecht, S. M., Dec 1 1991, In : Journal of Biological Chemistry. 266, 35, p. 23994-24002 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Synthesis of pyrimidoblamic acid and epipyrimidoblamic acid

Aoyagi, Y., Chorghade, M. S., Padmapriya, A. A., Suguna, H. & Hecht, S. M., Jan 1 1991, In : Journal of Organic Chemistry. 56, 1, p. 6291-6298 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis of Water-Soluble (Aminoalkyl)camptothecin Analogues: Inhibition of Topoisomerase I and Antitumor Activity

Kingsbury, W. D., Boehm, J. C., Jakas, D. R., Holden, K. G., Gallagher, G., Caranfa, M. J., McCabe, F. L., Faucette, L. F., Johnson, R. K., Hertzberg, R. P. & Hecht, S. M., Jan 1 1991, In : Journal of Medicinal Chemistry. 34, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

507 Scopus citations
1992

Amplification of protein expression in a cell free system

Resto, E., Lida, A., Cleve, M. D. V. & Hecht, S. M., Nov 25 1992, In : Nucleic acids research. 20, 22, p. 5979-5983 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

A strategy for identifying novel, mechanistically unique inhibitors of topoisomerase i

Hecht, S. M., Berry, D. E., Mackenzie, L. J., Busby, R. W. & Nasuti, C. A., Apr 1 1992, In : Journal of Natural Products. 55, 4, p. 401-413 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Naturally Occurring Inhibitors of Topoisomerase I Mediated DNA Relaxation

Berry, D. E., MacKenzie, L., Shultis, E. A., Chan, J. A. & Hecht, S. M., Jan 1 1992, In : Journal of Organic Chemistry. 57, 2, p. 420-422 3 p.

Research output: Contribution to journalArticle

49 Scopus citations

On the Role of Individual Bleomycin Thiazoles in Oxygen Activation and DNA Cleavage

Hamamichi, N., Natrajan, A. & Hecht, S. M., Jul 1 1992, In : Journal of the American Chemical Society. 114, 16, p. 6278-6291 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

Probing the synthetic capabilities of a center of biochemical catalysis

Hecht, S. M., Dec 1 1992, In : Accounts of chemical research. 25, 12, p. X-552

Research output: Contribution to journalArticle

9 Scopus citations

Probing the Synthetic Capabilities of a Center of Biochemical Catalysis

Hecht, S. M., Jan 1 1992, In : Accounts of chemical research. 25, 12, p. 545-552 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
1993

A new method for the synthesis of nitriles from amides under non-acidic conditions

Sznaidman, M. L., Crasto, C. & Hecht, S. M., Mar 5 1993, In : Tetrahedron Letters. 34, 10, p. 1581-1584 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Characterization of Iron(II)·Bleomycin-Mediated RNA Strand Scission

Holmes, C. E., Carter, B. J. & Hecht, S. M., Apr 1 1993, In : Biochemistry. 32, 16, p. 4293-4307 15 p.

Research output: Contribution to journalArticle

83 Scopus citations

Determination of the Absolute Configuration of the Thiazolinylthiazole Moiety of Phleomycin

Hamamichi, N. & Hecht, S. M., Dec 1 1993, In : Journal of the American Chemical Society. 115, 26, p. 12605-12606 2 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evidence for C-1' hydrogen abstraction from modified oligonucleotides by Fe-bleomycin

Duff, R. J., De Vroom, E., Geluk, A., Hecht, S. M., Van Der Marel, G. A. & Van Boom, J. H., Jan 1 1993, In : Journal of the American Chemical Society. 115, 8, p. 3350-3351 2 p.

Research output: Contribution to journalArticle

40 Scopus citations

Fe·bleomycin cleaves a transfer RNA precursor and its 'transfer DNA' analog at the same major site

Holmes, C. E. & Hecht, S. M., Jan 1 1993, In : Journal of Biological Chemistry. 268, 34, p. 25909-25913 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Highly Efficient DNA Strand Scission by Photoactivated Chlorobithiazoles

Quada, J. C., Levy, M. J. & Hecht, S. M., Dec 1 1993, In : Journal of the American Chemical Society. 115, 25, p. 12171-12172 2 p.

Research output: Contribution to journalArticle

57 Scopus citations

Inhibition of Topoisomerase I Function by Nitidine and Fagaronine

Wang, L. K., Hecht, S. M. & Johnson, R. K., Nov 1 1993, In : Chemical Research in Toxicology. 6, 6, p. 813-818 6 p.

Research output: Contribution to journalArticle

134 Scopus citations

Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum

Fang, S. D., Wang, L. K. & Hecht, S. M., Sep 10 1993, In : Journal of Organic Chemistry. 58, 19, p. 5025-5027 3 p.

Research output: Contribution to journalArticle

162 Scopus citations
1994

A Concise Synthesis of the Antifungal Agent (+)-Preussin

Overhand, M. & Hecht, S. M., Aug 1 1994, In : Journal of Organic Chemistry. 59, 17, p. 4721-4722 2 p.

Research output: Contribution to journalArticle

85 Scopus citations

Iron(II) Bleomycin-Mediated Degradation of a DNA-RNA Heteroduplex

Morgan, M. A. & Hecht, S. M., Aug 1 1994, In : Biochemistry. 33, 34, p. 10286-10293 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe·bleomycin

Kane, S. A., Natrajan, A. & Hecht, S. M., Apr 8 1994, In : Journal of Biological Chemistry. 269, 14, p. 10899-10904 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Polynucleotide Recognition and Degradation by Bleomycin

Kane, S. A. & Hecht, S. M., Jan 1 1994, In : Progress in Nucleic Acid Research and Molecular Biology. 49, C, p. 313-352 40 p.

Research output: Contribution to journalArticle

110 Scopus citations

Solution Structure of a Zn(II)·Bleomycin A5-d(CGCTAGCG)2 Complex

Manderville, R. A., Ellena, J. F. & Hecht, S. M., Nov 1 1994, In : Journal of the American Chemical Society. 116, 23, p. 10851-10852 2 p.

Research output: Contribution to journalArticle

75 Scopus citations
1995

5-Alkylresorcinols from Hakea trifurcata That Cleave DNA

Lytollis, W., Scannell, R. T., An, H., Murty, V. S., Reddy, K. S., Barr, J. R. & Hecht, S. M., Jan 1 1995, In : Journal of the American Chemical Society. 117, 51, p. 12683-12690 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

A Model for Topoisomerase I-Mediated Insertions And Deletions with Duplex DNA Substrates Containing Branches, Nicks, and Gaps

Henningfeld, K. A. & Hecht, S. M., May 1 1995, In : Biochemistry. 34, 18, p. 6120-6129 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Carbohydrate Cyclic Ketene Acetals

Sznaidman, M. L., Johnson, S. C., Crasto, C. & Hecht, S. M., Jun 1 1995, In : Journal of Organic Chemistry. 60, 13, p. 3942-3943 2 p.

Research output: Contribution to journalArticle

32 Scopus citations

DNA Cleavage by Di- and Trihydroxyalkylbenzenes. Characterization of Products and the Roles of O2, Cu(II), and Alkali

Singh, U. S., Scannell, R. T., An, H., Carter, B. J. & Hecht, S. M., Jan 1 1995, In : Journal of the American Chemical Society. 117, 51, p. 12691-12699 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Guanosine-specific DNA damage by a Co(II)·bithiazole complex

Kane, S. A., Sasaki, H. & Hecht, S. M., Sep 13 1995, In : Journal of the American Chemical Society. 117, 36, p. X-9117

Research output: Contribution to journalArticle

4 Scopus citations

Guanosine-Specific DNA Damage by a Co(II)-Bithiazole Complex

Kane, S. A., Sasaki, H. & Hecht, S. M., Jan 1 1995, In : Journal of the American Chemical Society. 117, 36, p. 9107-9118 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Interaction of Zn(II)·Bleomycin with d(CGCTAGCG)2· A Binding Model Based on NMR Experiments and Restrained Molecular Dynamics Calculations

Manderville, R. A., Ellena, J. F. & Hecht, S. M., Jan 1 1995, In : Journal of the American Chemical Society. 117, 30, p. 7891-7903 13 p.

Research output: Contribution to journalArticle

85 Scopus citations

Phosphoryl migration during the chemical synthesis of RNA

Morgan, M. A., Kazakov, S. A. & Hecht, S. M., Oct 11 1995, In : Nucleic acids research. 23, 19, p. 3949-3953 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sequence-Specific Hydrolysis of Yeast tRNAphe Mediated by Metal-Free Bleomycin

Keck, M. V. & Hecht, S. M., Sep 1995, In : Biochemistry. 34, 37, p. 12029-12037 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Specific Cleavage of a DNA Triple Helix by FeII.Bleomycin

Kane, S. A., Hecht, S. M., Sun, J. S., Garestier, T. & Hélène, C., Dec 1995, In : Biochemistry. 34, 51, p. 16715-16724 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
1996
34 Scopus citations

Enantiospecific total synthesis of (+)- and (-)-avarone and -avarol

Locke, E. P. & Hecht, S. M., Jan 1 1996, In : Chemical Communications. 24, p. 2717-2718 2 p.

Research output: Contribution to journalArticle

20 Scopus citations

Fe-bleomycin as a probe of RNA conformation

Holmes, C. E., Abraham, A. T., Hecht, S. M., Florentz, C. & Giegé, R., Sep 17 1996, In : Nucleic acids research. 24, 17, p. 3399-3406 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Firefly luciferase: Alteration of the color of emitted light resulting from substitutions at position 286

Mamaev, S. V., Laikhter, A. L., Arslan, T. & Hecht, S. M., Jul 31 1996, In : Journal of the American Chemical Society. 118, 30, p. 7243-7244 2 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne

Wang, L. K., Rogers, B. D. & Hecht, S. M., Jan 1 1996, In : Chemical Research in Toxicology. 9, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Modification of nucleic acid structure by DNA topoisomerase l

Henninqteld, K. A., Asian, T. & Hecht, S. M., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1241

Research output: Contribution to journalArticle