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1977

Isoenergetic Hydride Transfer. A Reversible, Phase Transition Mediated tRNA Modification

Hecht, S. M., Arcari, P. & Adams, B. L., Jan 1 1977, In : Journal of the American Chemical Society. 99, 11, p. 3890-3892 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Isomeric aminoacyl tRNAs are both bound by elongation factor Tu

Hecht, S. M., Hock Tan, K., Chinault, A. C. & Arcari, P., Jan 1 1977, In : Proceedings of the National Academy of Sciences of the United States of America. 74, 2, p. 437-441 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Participation of isomeric tRNA'S in the partial reactions of protein biosynthesis

Hecht, S. M., 1977, In : Tetrahedron. 33, 14, p. 1671-1696 26 p.

Research output: Contribution to journalArticle

37 Scopus citations

Preparation of Escherichia coli tRNAs Terminating in Modified Nucleosides by the Use of CTP(ATP): TRNA Nucleotidyltransferase and Polynucleotide Phosphorylase

Chinault, A. C., Kozarich, J. W., Hecht, S. M., Schmidt, F. J. & Bock, R. M., Feb 1 1977, In : Biochemistry. 16, 4, p. 756-765 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Utilization of Isomeric Aminoacyl Transfer Ribonucleic Acids in Peptide Bond Formation

Hecht, S. M., Jul 1 1977, In : Accounts of chemical research. 10, 7, p. 239-245 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
1978

2'- Versus 3'-OH specificity in tRNA aminoacylation. Further support for the 'secondary cognition' proposal

Alford, B. & Hecht, S. M., Jan 1 1978, In : Journal of Biological Chemistry. 253, 14, p. 4844-4850 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

"Chemical aminoacylation" of tRNA's.

Hecht, S. M., Alford, B. L., Kuroda, Y. & Kitano, S., Jul 10 1978, In : Journal of Biological Chemistry. 253, 13, p. 4517-4520 4 p.

Research output: Contribution to journalArticle

145 Scopus citations

Isoenergetic hydride transfer. A reversible tRNA modification with concomitant alteration of biochemical properties

Arcari, P. & Hecht, S. M., Dec 1 1978, In : Journal of Biological Chemistry. 253, 22, p. 8278-8284 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

The effect of 'cap' analogs on reovirus mRNA binding to wheat germ ribosomes. Evidence for enhancement of ribosomal binding via a preferred cap conformation

Adams, B. L., Morgan, M., Muthukrishnan, S., Hecht, S. M. & Shatkin, A. J., Aug 7 1978, In : Journal of Biological Chemistry. 253, 8, p. 2589-2595 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
1979

Both positional isomers of aminoacyl-tRNA's are bound by elongation factor Tu.

Alford, B. L., Pezzuto, J. M., Tan, K. H. & Hecht, S. M., Aug 10 1979, In : Journal of Biological Chemistry. 254, 15, p. 6894-6903 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.

Sonenberg, N., Rupprecht, K. M., Hecht, S. M. & Shatkin, A. J., Sep 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 9, p. 4345-4349 5 p.

Research output: Contribution to journalArticle

Open Access
149 Scopus citations

Nickel Peroxide Dehydrogenation of Oxygen-, Sulfur-, and Nitrogen-Containing Heterocycles

Evans, D. L., Minster, D. K., Jordis, U., Sidney, H. M., Mazzu, A. L. & Meyers, A. I., Jan 1 1979, In : Journal of Organic Chemistry. 44, 4, p. 497-501 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Preparation of tRNAs Terminating in 2′- and 3′-Deoxyadenosine

Alford, B. L., Craig Chinault, A., Jolly, S. O. & Hecht, S. M., Jan 1 1979, In : Methods in Enzymology. 59, C, p. 121-134 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Proton Nuclear Magnetic Resonance Study of the Structure of Bleomycin and the Zinc-Bleomycin Complex

Oppenheimer, N. J., Rodriguez, L. O. & Hecht, S. M., Jan 1 1979, In : Biochemistry. 18, 16, p. 3439-3445 7 p.

Research output: Contribution to journalArticle

68 Scopus citations
135 Scopus citations

Synthesis of L-erythro-β-Hydroxyhistidine from D-Glucosamine

Hecht, S. M., Rupprecht, K. M. & Jacobs, P. M., Jul 1 1979, In : Journal of the American Chemical Society. 101, 14, p. 3982-3983 2 p.

Research output: Contribution to journalArticle

37 Scopus citations

Transfer RNA control of the activation of isomeric tRNATrp's.

Alford, B. L. & Hecht, S. M., Aug 10 1979, In : Journal of Biological Chemistry. 254, 15, p. 6873-6875 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
1980

Amino acid substitutions in protein biosynthesis. Poly(A)-directed polyphenylalanine synthesis.

Pezzuto, J. M. & Hecht, S. M., Feb 10 1980, In : Journal of Biological Chemistry. 255, 3, p. 865-869 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Characterisation of guanidino-containing antibiotics: Field desorption mass spectrometry of bleomycin B2 and phleomycins D1 and E

Dell, A., Morris, H. R., Hecht, S. M. & Levin, M. D., Dec 16 1980, In : Biochemical and Biophysical Research Communications. 97, 3, p. 987-994 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Differential stimulation of capped mRNA translation in vitro by cap binding protein

Sonenberg, N., Trachsel, H., Hecht, S. & Shatkin, A. J., Dec 1 1980, In : Nature. 285, 5763, p. 331-333 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

Metal Binding to Modified Bleomycins. Zinc and Ferrous Complexes with an Acetylated Bleomycin

Oppenheimer, N. J., Rodriguez, L. O. & Hecht, S. M., Aug 1 1980, In : Biochemistry. 19, 17, p. 4096-4103 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Synthesis of the Pyrimidine Moieties of Bleomycin and Epibleomycin

Aral, H., Hagmann, W. K., Suguna, H. & Hecht, S. M., Oct 1980, In : Journal of the American Chemical Society. 102, 21, p. 6631-6633 3 p.

Research output: Contribution to journalArticle

28 Scopus citations

There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles

Pezzuto, J. M., Lau, P. P., Luh, Y., Moore, P. D., Wogan, G. N. & Hecht, S. M., Jan 1 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 3 I, p. 1427-1431 5 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
1981

Chemistry of 2-Substituted Pyrimidines. Studies Directed toward the Synthesis of the Pyrimidine Moiety of Bleomycin

Hagmann, W. K., Basha, F. Z., Hashimoto, M., Bruce Frye, R., Kojo, S. & Hecht, S. M., Mar 1981, In : Journal of Organic Chemistry. 46, 7, p. 1413-1423 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Copper(I)-bleomycin. A structurally unique oxidation-reduction active complex

Oppenheimer, N. J., Chang, C., Rodriguez, L. O. & Hecht, S. M., Jan 1 1981, In : Journal of Biological Chemistry. 256, 4, p. 1514-1517 4 p.

Research output: Contribution to journalArticle

35 Scopus citations

Design and Preparation of Affinity Columns for the Purification of Eukaryotic Messenger Ribonucleic Acid Cap Binding Protein

Rupprecht, K. M., Hecht, S. M., Sonenberg, N. & Shatki, A. J., Nov 1981, In : Biochemistry. 20, 23, p. 6570-6577 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

EFECTO DEL ANTIBIOTICO ANTITUMORAL BLEOMICINA EN LA ESTRUCTURA DEL NUCLEOIDE: ESTUDIOS DE SEDIMENTACION

Translated title of the contribution: Effect of antibiotic antitumoral bleomycin on nucleoid structure: Sedimentation studiesPellon, J. R., Hecht, S. M. & Gomez, R. F., Jan 1 1981, In : Revista Espanola de Fisiologia. 37, 3, p. 363-364 2 p.

Research output: Contribution to journalArticle

Field desorption and fast atom bombardment mass spectrometry of bleomycins and their derivatives

Dell, A., Morris, H. R., Levin, M. D. & Hecht, S. M., Sep 30 1981, In : Biochemical and Biophysical Research Communications. 102, 2, p. 730-738 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Metabolic Activation of 1-Methyl-3-amino-5H-pyrido[4,3-b]indole and Several Structurally Related Mutagens

Pezzuto, J. M., Moore, P. D. & Hecht, S. M., Jan 1981, In : Biochemistry. 20, 2, p. 298-305 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Synthesis of the Carbohydrate Moiety of Bleomycin

Pozsgay, V., Ohgi, T. & Hecht, S. M., Aug 1981, In : Journal of Organic Chemistry. 46, 18, p. 3761-3763 3 p.

Research output: Contribution to journalArticle

12 Scopus citations
1982

A structurally modified yeast tRNAPhe with six nucleotides in the anticodon loop lacks significant phenylalanine acceptance.

Nishikawa, K. & Hecht, S. M., Sep 25 1982, In : Journal of Biological Chemistry. 257, 18, p. 10536-10539 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Chemical Excision of Apurinic Acids from RNA. A Structurally Modified Yeast tRNAPhe

Nishikawa, K., Adams, B. L. & Hecht, S. M., Jan 1 1982, In : Journal of the American Chemical Society. 104, 1, p. 326-328 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Deglycobleomycin: Total Synthesis and Oxygen Transfer Properties of an Active Bleomycin Analogue

Aoyagi, Y., Suguna, H., Murugesan, N., Ehrenfeld, G. M., Chang, L. H., Ohgi, T., Shekhani, M. S., Kirkup, M. P. & Hecht, S. M., Jan 1 1982, In : Journal of the American Chemical Society. 104, 19, p. 5237-5239 3 p.

Research output: Contribution to journalArticle

48 Scopus citations

Deglyco-bleomycin. Degradation of DNA and formation of a structurally unique Fe(II).CO complex

Oppenheimer, N. J., Chang, C., Chang, L. H., Ehrenfeld, G., Rodriguez, L. O. & Hecht, S. M., Jul 2 1982, In : Journal of Biological Chemistry. 257, 4, p. 1606-1609 4 p.

Research output: Contribution to journalArticle

63 Scopus citations

Iron(II)-bleomycin. Biochemical and spectral properties in the presence of radical scavengers

Rodriguez, L. O. & Hecht, S. M., Feb 26 1982, In : Biochemical and Biophysical Research Communications. 104, 4, p. 1470-1476 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Oxygen transfer from bleomycin-metal complexes

Murugesan, N., Ehrenfeld, G. M. & Hecht, S. M., Dec 1 1982, In : Journal of Biological Chemistry. 257, 15, p. 8600-8603 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Specificity of Deoxyribonucleic Acid Cleavage by Bleomycin, Phleomycin, and Tallysomycin

Kross, J., Henner, W. D., Haseltine, W. A. & Hecht, S. M., Aug 1982, In : Biochemistry. 21, 18, p. 4310-4318 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Structural Basis for the Deoxyribonucleic Acid Affinity of Bleomycins

Kross, J., Henner, W. D., Haseltine, W. A., Rodriguez, L., Levin, M. D. & Hecht, S. M., Jul 1982, In : Biochemistry. 21, 15, p. 3711-3721 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Total Synthesis of Bleomycin

Aoyagi, Y., Katano, K., Suguna, H., Primeau, J., Chang, L. H. & Hecht, S. M., Jan 1 1982, In : Journal of the American Chemical Society. 104, 20, p. 5537-5538 2 p.

Research output: Contribution to journalArticle

64 Scopus citations
1983

Dipeptide formation with misacylated tRNA (Phe)S

Heckler, T. G., Zama, Y., Naka, T. & Hecht, S. M., Jan 1 1983, In : Journal of Biological Chemistry. 258, 7, p. 4492-4495 4 p.

Research output: Contribution to journalArticle

77 Scopus citations

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

Henner, W. D., Rodriguez, L. O., Hecht, S. M. & Haseltine, W. A., Jan 25 1983, In : Journal of Biological Chemistry. 258, 2, p. 711-713 3 p.

Research output: Contribution to journalArticle

282 Scopus citations

Kinetics of the bleomycin A2 damage in vivo to the folded chromosome of Escherichia coli

Pellon, J. R., Sinskey, A. J., Hecht, S. M. & Gomez, R. F., Feb 1983, In : Chemico-Biological Interactions. 43, 2, p. 245-251 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of positional specificity in the aminoacylation of Escherichia coli tRNAGly.

Ehrenfeld, G. M., Francis, T. A. & Hecht, S. M., Oct 10 1983, In : Journal of Biological Chemistry. 258, 19, p. 11745-11750 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

New cytotoxic principles from Datisca glomerata

Sasamori, H., Reddy, K. S., Kirkup, M. P., Shabanowitz, J., Lynn, D. G., Hecht, S. M., Woode, K. A., Bryan, R. F., Campbell, J., Lynn, W. S., Egert, E. & Sheldrick, G. M., Dec 1 1983, In : Journal of the Chemical Society, Perkin Transactions 1. p. 1333-1347 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Transfer RNA pyrophosphorolysis with CTP(ATP):tRNA nucleotidyltransferase. A direct route to tRNAs modified at the 3' terminus.

Francis, T. A., Ehrenfeld, G. M., Gregory, M. R. & Hecht, S. M., Apr 10 1983, In : Journal of Biological Chemistry. 258, 7, p. 4279-4284 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
1984

Activation of Oxygen and Mediation of DNA Degradation by Manganese-Bleomycin

Ehrenfeld, G. M., Murugesan, N. & Hecht, S. M., Dec 1984, In : Inorganic chemistry. 23, 11, p. 1496-1498 3 p.

Research output: Contribution to journalArticle

51 Scopus citations

Afromontoside. A new cytotoxic principle from Dracaena afromontana

Reddy, K. S., Shekhani, M. S., Berry, D. E., Lynn, D. G. & Hecht, S. M., Dec 1 1984, In : Journal of the Chemical Society, Perkin Transactions 1. p. 987-992 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Bleomycin May Be Activated for DNA Cleavage by NADPH-Cytochrome P-450 Reductase

Kilkuskie, R. E., Macdonald, T. L. & Hecht, S. M., Dec 1984, In : Biochemistry. 23, 25, p. 6165-6171 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Plant anticancer agents, XXXIV. cucurbitacins from elaeocarpus dolichostylus1'2

Pezzuto, J. M., Yellin, B., Fang, X., Phoebe, C. H., Fong, H. H. S., Farnsworth, N. R. & Hecht, S. M., Jan 1984, In : Journal of Natural Products. 47, 6, p. 988-993 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Preparation of '2,('3)-O-Acyl-pCpA derivatives as substrates for T4 RNA ligase-mediated "chemical aminoacylation"

Heckler, T. G., Chang, L. H., Zama, Y., Naka, T. & Hecht, S. M., 1984, In : Tetrahedron. 40, 1, p. 87-94 8 p.

Research output: Contribution to journalArticle

49 Scopus citations