ASU-Banner Neurodegenerative Disease Research Center (NDRC)

Research output

Research output per year 1999 2015 2017 2018 2019 2020 2021 2022 2024

• 129 Article
• 13 Review article
• 8 Comment/debate
• 4 Chapter
• 4 More
  • 2 Letter
  • 1 Conference contribution
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Quantitative assessment of multiple pathogen exposure and immune dynamics at scale

  Song, L., Rauf, F., Hou, C. W., Qiu, J., Murugan, V., Chung, Y., Lai, H., Adam, D., Magee, D. M., Trivino Soto, G., Peterson, M., Anderson, K. S., Rice, S. G., Readhead, B., Park, J. G. & LaBaer, J., Jan 11 2024, In: Microbiology Spectrum. 12, 1, p. e0239923

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • serology 100%
  • antigen 96%
  • Serology 87%
  • pathogen 76%
  • antigens 61%
• 2023

  BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT^P301S mouse model of tauopathy

  Perez-Garcia, G., Bicak, M., Haure-Mirande, J. V., Perez, G. M., Otero-Pagan, A., Gama Sosa, M. A., De Gasperi, R., Sano, M., Barlow, C., Gage, F. H., Readhead, B., Ehrlich, M. E., Gandy, S. & Elder, G. A., Feb 16 2023, In: Neuroscience Letters. 797, 137080.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BCI-838 100%
  • metabotropic glutamate receptor 2 64%
  • Drug Repositioning 57%
  • Tauopathies 57%
  • Prodrugs 46%
  1 Scopus citations

• Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseases

  Huseby, C. J., Delvaux, E., Brokaw, D. L. & Coleman, P. D., Jun 2023, In: Alzheimer's and Dementia. 19, 6, p. 2618-2632 15 p.

  Research output: Contribution to journal › Article › peer-review

  • dementia 100%
  • Neurodegenerative Diseases 86%
  • Alzheimer Disease 77%
  • RNA 68%
  • Transcriptome 26%
  3 Scopus citations

• Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA- binding protein 1

  Szczerba, M., Johnson, B., Acciai, F., Gogerty, C., McCaughan, M., Williams, J., Kibler, K. V. & Jacobs, B. L., Mar 14 2023, In: Science Signaling. 16, 776, eabq0837.

  Research output: Contribution to journal › Article › peer-review

  • Z-Form DNA 100%
  • Necroptosis 85%
  • arsenite 85%
  • DNA-Binding Proteins 68%
  • Protein 25%
  3 Scopus citations

• Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias

  PROSPECT Consortium, The American Genome Center, International LBD Genomics Consortium & International ALS/FTD Consortium, Jun 14 2023, In: Cell Genomics. 3, 6, 100316.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genomic Structural Variation 100%
  • Frontotemporal Dementia With Motor Neuron Disease 92%
  • Lewy Body Disease 76%
  • Pipeline 69%
  • Dementia 50%
  4 Scopus citations

• Integrated DNA Methylation/RNA Profiling in Middle Temporal Gyrus of Alzheimer’s Disease

  Piras, I. S., Brokaw, D., Kong, Y., Weisenberger, D. J., Krate, J., Delvaux, E., Mahurkar, S., Blattler, A., Siegmund, K. D., Sue, L., Serrano, G. E., Beach, T. G., Laird, P. W., Huentelman, M. J. & Coleman, P. D., Jul 2023, In: Cellular and Molecular Neurobiology. 43, 5, p. 2289-2307 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Epigenome 94%
  • Temporal Lobe 93%
  • Alzheimer Disease 78%
  • RNA 70%
  3 Scopus citations

• Intracellular Amyloid-β Detection from Human Brain Sections Using a Microfluidic Immunoassay in Tandem with MALDI-MS

  Villarreal, J. C., Kow, K., Pham, B., Egatz-Gomez, A., Sandrin, T. R., Coleman, P. D. & Ros, A., Apr 4 2023, In: Analytical Chemistry. 95, 13, p. 5522-5531 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurotoxic 100%
  • Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry 90%
  • Immunoassay 73%
  • Oligomer 31%
  • Peptide 22%

• Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G

  Smullen, M., Olson, M. N., Murray, L. F., Suresh, M., Yan, G., Dawes, P., Barton, N. J., Mason, J. N., Zhang, Y., Fernandez-Fontaine, A. A., Church, G. M., Mastroeni, D., Wang, Q., Lim, E. T., Chan, Y. & Readhead, B., Dec 2023, In: Scientific reports. 13, 1, 10405.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Polymorphisms 100%
  • Alzheimer Disease 73%
  • Quantitative Trait Loci 59%
  • Brain 46%
  • Cell Line 42%
  2 Scopus citations

• REDD1 (regulated in development and DNA damage 1) modulates the glucocorticoid receptor function in keratinocytes

  Chudakova, D. A., Trubetskoy, D., Baida, G., Bhalla, P., Readhead, B. & Budunova, I., Oct 2023, In: Experimental Dermatology. 32, 10, p. 1725-1733 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucocorticoid 100%
  • Glucocorticoid Receptors 86%
  • Keratinocytes 75%
  • DNA 43%
  • tacrolimus binding protein 4 22%

• Reliable multiplex generation of pooled induced pluripotent stem cells

  Smullen, M., Olson, M. N., Reichert, J. M., Dawes, P., Murray, L. F., Baer, C. E., Wang, Q., Readhead, B., Church, G. M., Lim, E. T. & Chan, Y., Sep 25 2023, In: Cell Reports Methods. 3, 9, 100570.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells 100%
  • Pluripotent Stem Cells 82%
  • Induced Pluripotent Stem Cells 80%
  • Donor 48%
  • Stem Cell Research 18%
• 2022

  Blood Transcript Biomarkers Selected by Machine Learning Algorithm Classify Neurodegenerative Diseases including Alzheimer’s Disease

  Huseby, C. J., Delvaux, E., Brokaw, D. L. & Coleman, P. D., Nov 2022, In: Biomolecules. 12, 11, 1592.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Machine Learning 100%
  • Biological Marker 79%
  • Neurodegenerative Diseases 76%
  • Alzheimer Disease 68%
  • Biomarkers 57%
  6 Scopus citations

• Chronic Cognitive and Cerebrovascular Function after Mild Traumatic Brain Injury in Rats

  Griffiths, D. R., Law, L. M., Young, C., Fuentes, A., Truran, S., Karamanova, N., Bell, L. C., Turner, G., Emerson, H., Mastroeni, D., Gonzales, R. J., Reaven, P. D., Quarles, C. C., Migrino, R. Q. & Lifshitz, J., Oct 1 2022, In: Journal of Neurotrauma. 39, 19-20, p. 1429-1441 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Concussion 100%
  • Psychology Recognition 69%
  • Smooth Muscle 69%
  • Cognition 62%
  • Cerebrovascular Circulation 45%
  5 Scopus citations

• Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer's disease

  Wang, Q., Chen, K., Su, Y., Reiman, E. M., Dudley, J. T. & Readhead, B., 2022, In: Brain Communications. 4, 1, fcab293.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alzheimer Disease 56%
  • Brain 35%
  • Neuropathology 18%
  • Gene Regulatory Networks 17%
  • Datasets 12%
  6 Scopus citations

• DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity

  Zhu, B., Parsons, T., Foley, C., Shaw, Y., Dunckley, T., Hulme, C. & Hodge, J. J. L., Dec 2022, In: Scientific reports. 12, 1, 15847.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dyrk kinase 100%
  • Down Syndrome 58%
  • Amyloid 53%
  • Alzheimer Disease 43%
  • Amyloid beta-Protein Precursor 32%
  4 Scopus citations

• Improving community health-care systems’ early detection of cognitive decline and dementia

  PAD 20/20 Work Group on Community-Based Detection of Cognitive Decline and Dementia, Nov 2022, In: Alzheimer's and Dementia. 18, 11, p. 2375-2381 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Community Health Planning 100%
  • Community Health Services 82%
  • Health Care System 66%
  • dementia 66%
  • Dementia 55%
  1 Scopus citations

• Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501Y_MA30 Strain of SARS-CoV-2

  Kibler, K. V., Szczerba, M., Lake, D., Roeder, A. J., Rahman, M., Hogue, B. G., Roy Wong, L. Y., Perlman, S., Li, Y. & Jacobs, B. L., Aug 2022, In: Vaccines. 10, 8, 1172.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intranasal 100%
  • SARS Virus 91%
  • Vaccinia virus 74%
  • Lethal 74%
  • Immunization 52%
  4 Scopus citations

• MIMAS: microfluidic platform in tandem with MALDI mass spectrometry for protein quantification from small cell ensembles

  Cruz Villarreal, J., Kruithoff, R., Egatz-Gomez, A., Coleman, P. D., Ros, R., Sandrin, T. R. & Ros, A., May 2022, In: Analytical and bioanalytical chemistry. 414, 13, p. 3945-3958 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microfluidics 100%
  • Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry 99%
  • Statistical Ensemble 82%
  • Mass Spectrometry 75%
  • Protein 34%
  2 Scopus citations

• Potential for a Plant-Made SARS-CoV-2 Neutralizing Monoclonal Antibody as a Synergetic Cocktail Component

  Jugler, C., Sun, H., Grill, F., Kibler, K., Esqueda, A., Lai, H., Li, Y., Lake, D. & Chen, Q., May 2022, In: Vaccines. 10, 5, 772.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Neutralizing Antibodies 77%
  • Monoclonal Antibodies 56%
  • Epitope 31%
  8 Scopus citations

• Systematic evaluating and modeling of SARS-CoV-2 UVC disinfection

  Freeman, S., Kibler, K., Lipsky, Z., Jin, S., German, G. K. & Ye, K., Dec 2022, In: Scientific reports. 12, 1, 5869.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Disinfection 80%
  • Ultraviolet Rays 52%
  • Culture Media 46%
  • Viruses 45%
  10 Scopus citations

• Targeted Methylation Profiling of Single Laser-Capture Microdissected Post-Mortem Brain Cells by Adapted Limiting Dilution Bisulfite Pyrosequencing (LDBSP)

  Riemens, R. J. M., Kenis, G., Nolz, J., Susano Chaves, S. C., Duroux, D., Pishva, E., Mastroeni, D., Van Steen, K., Haaf, T. & van den Hove, D. L. A., Dec 2022, In: International journal of molecular sciences. 23, 24, 15571.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microdissection 100%
  • Methylation 83%
  • methylation 82%
  • Laser Capture Microdissection 71%
  • hydrogen sulfite 66%
  1 Scopus citations

• The Omnipresence of DYRK1A in Human Diseases

  Deboever, E., Fistrovich, A., Hulme, C. & Dunckley, T., Aug 2022, In: International journal of molecular sciences. 23, 16, 9355.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Drug 100%
  • tyrosine 88%
  • regulators 80%
  • Protein 78%
  • health 66%
  13 Scopus citations
• 2021

  Altered sphingolipid function in Alzheimer's disease; a gene regulatory network approach

  Giovagnoni, C., Ali, M., Eijssen, L. M. T., Maes, R., Choe, K., Mulder, M., Kleinjans, J., del Sol, A., Glaab, E., Mastroeni, D., Delvaux, E., Coleman, P., Losen, M., Pishva, E., Martinez-Martinez, P. & van den Hove, D. L. A., Jun 2021, In: Neurobiology of Aging. 102, p. 178-187 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sphingolipids 100%
  • Gene Regulatory Networks 88%
  • Alzheimer Disease 63%
  • Epigenomics 17%
  • Genes 16%
  8 Scopus citations

• A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex

  Smith, R. G., Pishva, E., Shireby, G., Smith, A. R., Roubroeks, J. A. Y., Hannon, E., Wheildon, G., Mastroeni, D., Gasparoni, G., Riemenschneider, M., Giese, A., Sharp, A. J., Schalkwyk, L., Haroutunian, V., Viechtbauer, W., van den Hove, D. L. A., Weedon, M., Brokaw, D., Francis, P. T., Thomas, A. J., & 8 othersLove, S., Morgan, K., Walter, J., Coleman, P. D., Bennett, D. A., De Jager, P. L., Mill, J. & Lunnon, K., Dec 1 2021, In: Nature communications. 12, 1, 3517.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenome 100%
  • cortexes 93%
  • Neuropathology 90%
  • loci 89%
  • methylation 63%
  48 Scopus citations

• Association of Variants in the SPTLC1 Gene with Juvenile Amyotrophic Lateral Sclerosis

  Johnson, J. O., Chia, R., Miller, D. E., Li, R., Kumaran, R., Abramzon, Y., Alahmady, N., Renton, A. E., Topp, S. D., Gibbs, J. R., Cookson, M. R., Sabir, M. S., Dalgard, C. L., Troakes, C., Jones, A. R., Shatunov, A., Iacoangeli, A., Al Khleifat, A., Ticozzi, N., Silani, V., & 268 othersGellera, C., Blair, I. P., Dobson-Stone, C., Kwok, J. B., Bonkowski, E. S., Palvadeau, R., Tienari, P. J., Morrison, K. E., Shaw, P. J., Al-Chalabi, A., Brown, R. H., Calvo, A., Mora, G., Al-Saif, H., Gotkine, M., Leigh, F., Chang, I. J., Perlman, S. J., Glass, I., Scott, A. I., Shaw, C. E., Basak, A. N., Landers, J. E., Chiò, A., Crawford, T. O., Smith, B. N., Traynor, B. J., Smith, B. N., Fallini, C., Gkazi, A. S., Topp, S. D., Scotter, E. L., Kenna, K. P., Keagle, P., Tiloca, C., Vance, C., Troakes, C., Colombrita, C., King, A., Pensato, V., Castellotti, B., Baas, F., Ten Asbroek, A. L. M. A., McKenna-Yasek, D., McLaughlin, R. L., Polak, M., Asress, S., Esteban-Pérez, J., Stevic, Z., D'Alfonso, S., Mazzini, L., Comi, G. P., Del Bo, R., Ceroni, M., Gagliardi, S., Querin, G., Bertolin, C., Van Rheenen, W., Rademakers, R., Van Blitterswijk, M., Lauria, G., Duga, S., Corti, S., Cereda, C., Corrado, L., Sorarù, G., Williams, K. L., Nicholson, G. A., Blair, I. P., Leblond-Manry, C., Rouleau, G. A., Hardiman, O., Morrison, K. E., Veldink, J. H., Van Den Berg, L. H., Pall, H., Turner, M. R., Talbot, K., Taroni, F., García-Redondo, A., Wu, Z., Glass, J. D., Gellera, C., Ratti, A., Brown, R. H., Landers, J. E., Dalgard, C. L., Adeleye, A., Soltis, A. R., Alba, C., Viollet, C., Bacikova, D., Hupalo, D. N., Sukumar, G., Pollard, H. B., Wilkerson, M. D., Martinez, E. M. G., Abramzon, Y., Ahmed, S., Arepalli, S., Baloh, R. H., Bowser, R., Brady, C. B., Brice, A., Broach, J., Campbell, R. H., Camu, W., Cooper-Knock, J., Ding, J., Drepper, C., Drory, V. E., Dunckley, T. L., Eicher, J. D., England, B. K., Faghri, F., Feldman, E., Floeter, M. K., Fratta, P., Geiger, J. T., Gerhard, G., Gibbs, J. R., Gibson, S. B., Glass, J. D., Hardy, J., Harms, M. B., Heiman-Patterson, T. D., Hernandez, D. G., Jansson, L., Kirby, J., Kowall, N. W., Laaksovirta, H., Landeck, N., Landi, F., Le Ber, I., Lumbroso, S., Macgowan, D. J. L., Maragakis, N. J., Mouzat, K., Murphy, N. A., Myllykangas, L., Nalls, M. A., Orrell, R. W., Ostrow, L. W., Pamphlett, R., Pickering-Brown, S., Pioro, E. P., Pletnikova, O., Pliner, H. A., Pulst, S. M., Ravits, J. M., Renton, A. E., Rivera, A., Robberecht, W., Rogaeva, E., Rollinson, S., Rothstein, J. D., Scholz, S. W., Sendtner, M., Sidle, K. C., Simmons, Z., Singleton, A. B., Smith, N., Stone, D. J., Tienari, P. J., Troncoso, J. C., Valori, M., Van Damme, P., Van Deerlin, V. M., Van Den Bosch, L., Zinman, L., Landers, J. E., Chiò, A., Traynor, B. J., Angelocola, S. M., Ausiello, F. P., Barberis, M., Bartolomei, I., Battistini, S., Bersano, E., Bisogni, G., Borghero, G., Brunetti, M., Cabona, C., Calvo, A., Canale, F., Canosa, A., Cantisani, T. A., Capasso, M., Caponnetto, C., Cardinali, P., Carrera, P., Casale, F., Chiò, A., Colletti, T., Conforti, F. L., Conte, A., Conti, E., Corbo, M., Cuccu, S., Dalla Bella, E., D'Errico, E., Demarco, G., Dubbioso, R., Ferrarese, C., Ferraro, P. M., Filippi, M., Fini, N., Floris, G., Fuda, G., Gallone, S., Gianferrari, G., Giannini, F., Grassano, M., Greco, L., Iazzolino, B., Introna, A., La Bella, V., Lattante, S., Liguori, R., Logroscino, G., Logullo, F. O., Lunetta, C., Mandich, P., Mandrioli, J., Manera, U., Manganelli, F., Marangi, G., Marinou, K., Marrosu, M. G., Martinelli, I., Messina, S., Moglia, C., Mosca, L., Murru, M. R., Origone, P., Passaniti, C., Petrelli, C., Petrucci, A., Pozzi, S., Pugliatti, M., Quattrini, A., Ricci, C., Riolo, G., Riva, N., Russo, M., Sabatelli, M., Salamone, P., Salivetto, M., Salvi, F., Santarelli, M., Sbaiz, L., Sideri, R., Simone, I., Simonini, C., Spataro, R., Tanel, R., Tedeschi, G., Ticca, A., Torriello, A., Tranquilli, S., Tremolizzo, L., Trojsi, F., Vasta, R., Vacchiano, V., Vita, G., Volanti, P., Zollino, M. & Zucchi, E., Oct 1 2021, In: JAMA Neurology. 78, 10, p. 1236-1248 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Genes 37%
  • Whole Exome Sequencing 23%
  • Hereditary Sensory and Autonomic Neuropathies 10%
  • Failure to Thrive 8%
  42 Scopus citations

• DNA Methylation and Expression Profiles of Whole Blood in Parkinson’s Disease

  Henderson, A. R., Wang, Q., Meechoovet, B., Siniard, A. L., Naymik, M., De Both, M., Huentelman, M. J., Caselli, R. J., Driver-Dunckley, E. & Dunckley, T., Apr 26 2021, In: Frontiers in Genetics. 12, 640266.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Parkinson Disease 84%
  • Hematologic Diseases 47%
  • Mitochondrial Parkinson Disease 37%
  • Methylation 36%
  33 Scopus citations

• Highly Sensitive and Multiplexed Protein Imaging With Cleavable Fluorescent Tyramide Reveals Human Neuronal Heterogeneity

  Liao, R., Mondal, M., Nazaroff, C. D., Mastroeni, D., Coleman, P. D., Labaer, J. & Guo, J., Jan 8 2021, In: Frontiers in Cell and Developmental Biology. 8, 614624.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteins 100%
  • Neurons 71%
  • Hippocampus 62%
  • Formaldehyde 36%
  • Paraffin 36%
  8 Scopus citations

• Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease

  Paes, D., Lardenoije, R., Carollo, R. M., Roubroeks, J. A. Y., Schepers, M., Coleman, P., Mastroeni, D., Delvaux, E., Pishva, E., Lunnon, K., Vanmierlo, T., van den Hove, D. & Prickaerts, J., Jan 2021, In: Neurobiology of Aging. 97, p. 56-64 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type 4 Cyclic Nucleotide Phosphodiesterase 100%
  • Cognitive Dysfunction 56%
  • Protein Isoforms 55%
  • Alzheimer Disease 53%
  • Pathology 43%
  15 Scopus citations

• IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer’s Disease Associated With Brain Weight

  Winslow, W., McDonough, I., Tallino, S., Decker, A., Vural, A. S. & Velazquez, R., Aug 13 2021, In: Frontiers in Aging Neuroscience. 13, 720214.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alzheimer Disease 100%
  • Weights and Measures 81%
  • Brain 63%
  • Cognition 33%
  • Rodentia 23%
  9 Scopus citations

• Maternal Choline Supplementation as a Potential Therapy for Down Syndrome: Assessment of Effects Throughout the Lifespan

  Powers, B. E., Velazquez, R., Strawderman, M. S., Ginsberg, S. D., Mufson, E. J. & Strupp, B. J., Oct 6 2021, In: Frontiers in Aging Neuroscience. 13, 723046.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Choline 100%
  • Down Syndrome 97%
  • Longevity 83%
  • Mothers 59%
  • Pregnancy 28%
  6 Scopus citations

• Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

  The PROSPECT Consortium, The American Genome Center (TAGC), The FALS Sequencing Consortium, The Genomics England Research Consortium, The International ALS/FTD Genomics Consortium (iAFGC), The International FTD Genetics Consortium (IFGC), The International LBD Genomics Consortium (iLBDGC), The NYGC ALS Consortium & the University of Maryland Brain and Tissue Bank and NIH NeuroBioBank, Feb 3 2021, In: Neuron. 109, 3, p. 448-460.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia With Motor Neuron Disease 100%
  • Lewy Body Disease 23%
  • Huntington Disease 10%
  • Genetic Testing 9%
  • Ubiquitin 9%
  53 Scopus citations

• Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease

  Morshed, N., Lee, M. J., Rodriguez, F. H., Lauffenburger, D. A., Mastroeni, D. & White, F. M., Jun 2021, In: Nature Aging. 1, 6, p. 550-565 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Alzheimer Disease 100%
  • Phosphotransferases 99%
  • Peptides 65%
  • Phosphorylation 35%
  • Pathology 32%
  13 Scopus citations

• Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis

  Bhattacharya, D., Becker, C., Readhead, B., Goossens, N., Novik, J., Fiel, M. I., Cousens, L. P., Magnusson, B., Backmark, A., Hicks, R., Dudley, J. T. & Friedman, S. L., Dec 2021, In: Scientific reports. 11, 1, 20827.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • lesogaberan 100%
  • GABA-B Receptor Agonists 74%
  • Fatty Liver 50%
  • obeticholic acid 11%
  • Drug Repositioning 9%
  6 Scopus citations

• Systems modeling of metabolic dysregulation in neurodegenerative diseases

  Baloni, P., Funk, C. C., Readhead, B. & Price, N. D., Oct 2021, In: Current Opinion in Pharmacology. 60, p. 59-65 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Neurodegenerative Diseases 100%
  • Metabolic 93%
  • Marker 33%
  • Systems Biology 27%
  • Huntington Disease 25%
  6 Scopus citations

• The viral hypothesis: how herpesviruses may contribute to Alzheimer’s disease

  Wainberg, M., Luquez, T., Koelle, D. M., Readhead, B., Johnston, C., Darvas, M. & Funk, C. C., Oct 2021, In: Molecular Psychiatry. 26, 10, p. 5476-5480 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Herpesviridae 100%
  • Alzheimer Disease 67%
  • Infections 41%
  • Amyloid 41%
  • Population 16%
  17 Scopus citations
• 2020

  Alterations in innate immunity and epithelial cell differentiation are the molecular pillars of hidradenitis suppurativa

  Zouboulis, C. C., Nogueira da Costa, A., Makrantonaki, E., Hou, X. X., Almansouri, D., Dudley, J. T., Edwards, H., Readhead, B., Balthasar, O., Jemec, G. B. E., Bonitsis, N. G., Nikolakis, G., Trebing, D., Zouboulis, K. C. & Hossini, A. M., Apr 1 2020, In: Journal of the European Academy of Dermatology and Venereology. 34, 4, p. 846-861 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hidradenitis Suppurativa 100%
  • Innate Immunity 63%
  • Cell Differentiation 56%
  • Epithelial Cells 49%
  • Skin 8%
  60 Scopus citations

• Amyloid β analysis from microdissected brain cells using microfluidics and maldi mass spectrometry

  Villarreal, J. C., Egatz-Gomez, A., Liu, J., Ros, R., Coleman, P. D. & Ros, A., 2020, MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 711-712 2 p. (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Amyloid 100%
  • Mass spectrometry 75%
  • Microfluidics 62%
  • Brain 48%
  • Mass Spectrometry 39%
  2 Scopus citations

• Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets

  Brokaw, D. L., Piras, I. S., Mastroeni, D., Weisenberger, D. J., Nolz, J., Delvaux, E., Serrano, G. E., Beach, T. G., Huentelman, M. J. & Coleman, P. D., Nov 2020, In: Neurobiology of Aging. 95, p. 15-25 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Datasets 100%
  • Alzheimer Disease 98%
  • Cell Survival 96%
  • Cell Death 96%
  • Apoptosis 77%
  21 Scopus citations

• Choline as a prevention for Alzheimer's disease

  Velazquez, R., Winslow, W. & Mifflin, M. A., Feb 9 2020, In: Aging. 12, 3, p. 2026-2027 2 p.

  Research output: Contribution to journal › Article › peer-review
  6 Scopus citations

• Do infections have a role in the pathogenesis of Alzheimer disease?

  Itzhaki, R. F., Golde, T. E., Heneka, M. T. & Readhead, B., Apr 1 2020, In: Nature Reviews Neurology. 16, 4, p. 193-197 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Alzheimer Disease 100%
  • Infections 61%
  • Traction 34%
  • Drug Development 30%
  • Brain 15%
  88 Scopus citations

• Genome sequences of novel torque teno viruses identified in human brain tissue

  Kraberger, S., Mastroeni, D., Delvaux, E. & Varsani, A., Sep 2020, In: Microbiology Resource Announcements. 9, 37, e00924-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Torque teno virus 100%
  • Genome 44%
  • Nucleotides 35%
  • Brain 32%
  • Open Reading Frames 21%
  3 Scopus citations

• Highly Sensitive and Multiplexed In-Situ Protein Profiling with Cleavable Fluorescent Streptavidin

  Liao, R., Pham, T., Mastroeni, D., Coleman, P. D., Labaer, J. & Guo, J., Apr 1 2020, In: Cells. 9, 4, 1786.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Streptavidin 100%
  • Biotin 53%
  • Protein 32%
  • Proteins 28%
  • Antibodies 16%
  7 Scopus citations

• Highly Sensitive and Multiplexed In-Situ Protein Profiling with Cleavable Fluorescent Streptavidin

  Liao, R., Pham, T., Mastroeni, D., Coleman, P., LaBaer, J. & Guo, J., 2020, In: Cells. 9, 4, p. 852

  Research output: Contribution to journal › Article › peer-review

• Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

  Wang, Q., Chen, Y., Readhead, B., Chen, K., Su, Y., Reiman, E. M. & Dudley, J. T., Dec 2020, In: Clinical Epigenetics. 12, 1, 189.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Quantitative Trait Loci 100%
  • Disease Progression 63%
  • Alzheimer Disease 61%
  • Methylation 32%
  • DNA Methylation 28%
  18 Scopus citations

• Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

  Velazquez, R., Ferreira, E., Winslow, W., Dave, N., Piras, I. S., Naymik, M., Huentelman, M. J., Tran, A., Caccamo, A. & Oddo, S., Oct 1 2020, In: Molecular Psychiatry. 25, 10, p. 2620-2629 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Homocysteine 100%
  • Choline 98%
  • Alzheimer Disease 71%
  • Mothers 59%
  • Pathology 58%
  43 Scopus citations

• miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease

  Readhead, B., Haure-Mirande, J. V., Mastroeni, D., Audrain, M., Fanutza, T., Kim, S. H., Blitzer, R. D., Gandy, S., Dudley, J. T. & Ehrlich, M. E., Sep 1 2020, In: Acta Neuropathologica. 140, 3, p. 295-315 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuropathology 100%
  • Alzheimer Disease 69%
  • Human Herpesvirus 6 60%
  • peptide A 33%
  • Brain 32%
  21 Scopus citations

• Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration

  Morshed, N., Ralvenius, W. T., Nott, A., Watson, L. A., Rodriguez, F. H., Akay, L. A., Joughin, B. A., Pao, P. C., Penney, J., LaRocque, L., Mastroeni, D., Tsai, L. H. & White, F. M., Dec 2020, In: Molecular Systems Biology. 16, 12, e9819.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microglia 100%
  • Sialic Acid Binding Immunoglobulin-like Lectins 79%
  • Sialic Acid 55%
  • inflammation 45%
  • Human 45%
  19 Scopus citations

• Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin

  Baida, G., Agarwal, S., Readhead, B., Dudley, J. T. & Budunova, I., Jan 28 2020, In: Oncotarget. 11, 4, p. 409-418 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fluocinolone Acetonide 100%
  • Sex Characteristics 85%
  • Glucocorticoids 83%
  • DNA Damage 80%
  • Atrophy 53%
  7 Scopus citations

• Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen

  Smith, M. R., Yevoo, P., Sadahiro, M., Readhead, B., Kidd, B., Dudley, J. T. & Morishita, H., 2020, In: Neural plasticity. 2020, 1673897.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • pyridaben 100%
  • Computational Biology 90%
  • Bacitracin 69%
  • Vehicle Emissions 66%
  • Gene Expression 57%
• 2019

  Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood

  Lardenoije, R., Roubroeks, J. A. Y., Pishva, E., Leber, M., Wagner, H., Iatrou, A., Smith, A. R., Smith, R. G., Eijssen, L. M. T., Kleineidam, L., Kawalia, A., Hoffmann, P., Luck, T., Riedel-Heller, S., Jessen, F., Maier, W., Wagner, M., Hurlemann, R., Kenis, G., Ali, M., & 9 othersDel Sol, A., Mastroeni, D., Delvaux, E., Coleman, P. D., Mill, J., Rutten, B. P. F., Lunnon, K., Ramirez, A. & Van Den Hove, D. L. A., Nov 27 2019, In: Clinical Epigenetics. 11, 1, 164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alzheimer Disease 100%
  • 5-Methylcytosine 68%
  • Brain 63%
  • Epigenome 60%
  • Cytosine 57%
  68 Scopus citations

• AmpliSeq transcriptome of laser captured neurons from Alzheimer brain: Comparison of single cell versus neuron pools

  Deng, W., Xing, C., David, R., Mastroeni, D., Ning, M. M., Lo, E. H. & Coleman, P. D., 2019, In: Aging and Disease. 10, 6, p. 1146-1158 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcriptome 100%
  • Lasers 87%
  • Alzheimer Disease 84%
  • Neurons 66%
  • Brain 53%
  4 Scopus citations