BI: ASU-Banner Neurodegenerative Disease Research Center (NDRC)

Research Output

2020

Choline as a prevention for Alzheimer's disease

Velazquez, R., Winslow, W. & Mifflin, M. A., Feb 9 2020, In : Aging. 12, 3, p. 2026-2027 2 p.

Research output: Contribution to journalArticle

2019

AmpliSeq transcriptome of laser captured neurons from Alzheimer brain: Comparison of single cell versus neuron pools

Deng, W., Xing, C., David, R., Mastroeni, D., Ning, M. M., Lo, E. H. & Coleman, P. D., Jan 1 2019, In : Aging and Disease. 10, 6, p. 1146-1158 13 p.

Research output: Contribution to journalArticle

Open Access

Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., De Both, M. D., Mastroeni, D., Serrano, G. E., Sue, L. I., Beach, T. G., Coleman, P. & Huentelman, M. J., Sep 15 2019, In : Brain Research. 1719, p. 217-224 8 p.

Research output: Contribution to journalArticle

Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice

Velazquez, R., Meechoovet, B., Ow, A., Foley, C., Shaw, A., Smith, B., Oddo, S., Hulme, C. & Dunckley, T., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

2 Scopus citations

Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits (BMC Medical Genomics DOI: 10.1186/s12920-019-0542-3)

Glicksberg, B. S., Amadori, L., Akers, N. K., Sukhavasi, K., Franzén, O., Li, L., Belbin, G. M., Ayers, K. L., Shameer, K., Badgeley, M. A., Johnson, K. W., Readhead, B., Darrow, B. J., Kenny, E. E., Betsholtz, C., Ermel, R., Skogsberg, J., Ruusalepp, A., Schadt, E. E., Dudley, J. T. & 6 others, Ren, H., Kovacic, J. C., Giannarelli, C., Li, S. D., Björkegren, J. L. M. & Chen, R., Nov 5 2019, In : BMC Medical Genomics. 12, 1, 154.

Research output: Contribution to journalComment/debate

Open Access

Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice

Vartak, R. S., Rodin, A. & Oddo, S., Nov 2019, In : Neurobiology of Aging. 83, p. 105-113 9 p.

Research output: Contribution to journalArticle

DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood

Harvard Biomarkers Study investigators are listed in the Acknowledgement section, Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

4 Scopus citations

Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans

Xu, K., Kosoy, R., Shameer, K., Kumar, S., Liu, L., Readhead, B., Belbin, G. M., Lee, H. C., Chen, R. & Dudley, J. T., Jul 2 2019, In : BMC Genetics. 20, 1, 52.

Research output: Contribution to journalArticle

Open Access

Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning

Willeman, M. N., Chawla, M. K., Zempare, M. A., Biwer, L. A., Hoang, L. T., Uprety, A. R., Fitzhugh, M. C., De Both, M., Coleman, P., Trouard, T. P., Alexander, G. E., Mitchell, K. D., Barnes, C. A., Hale, T. M. & Huentelman, M., Mar 1 2019, In : Physiological Reports. 7, 6, e14010.

Research output: Contribution to journalArticle

Open Access

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

Zhang, W., Voloudakis, G., Rajagopal, V. M., Readhead, B., Dudley, J. T., Schadt, E. E., Björkegren, J. L. M., Kim, Y., Fullard, J. F., Hoffman, G. E. & Roussos, P., Dec 1 2019, In : Nature communications. 10, 1, 3834.

Research output: Contribution to journalArticle

Open Access

Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation

Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W. & Oddo, S., Dec 1 2019, In : Aging Cell. 18, 6, e13037.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generations

Velazquez, R., Ferreira, E., Winslow, W., Dave, N., Piras, I. S., Naymik, M., Huentelman, M. J., Tran, A., Caccamo, A. & Oddo, S., Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

4 Scopus citations

PI3K inhibitors protect against glucocorticoid-induced skin atrophy

Agarwal, S., Mirzoeva, S., Readhead, B., Dudley, J. T. & Budunova, I., Jan 1 2019, In : EBioMedicine.

Research output: Contribution to journalArticle

3 Scopus citations

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

The ITALSGEN Consortium & The International ALS Genomics Consortium, Apr 1 2019, In : Annals of Neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Systems pharmacology identifies an arterial wall regulatory gene network mediating coronary artery disease side effects of antiretroviral therapy

Frades, I., Readhead, B., Amadori, L., Koplev, S., Talukdar, H. A., Crane, H. M., Crane, P. K., Kovacic, J. C., Dudley, J. T., Giannarelli, C., Björkegren, J. L. M. & Peter, I., Jan 1 2019, In : Circulation: Genomic and Precision Medicine. 12, 6, p. 262-272 11 p.

Research output: Contribution to journalArticle

Tau positron-emission tomography in former national football league players

Stern, R. A., Adler, C. H., Chen, K., Navitsky, M., Luo, J., Dodick, D. W., Alosco, M. L., Tripodis, Y., Goradia, D. D., Martin, B., Mastroeni, D., Fritts, N. G., Jarnagin, J., Devous, M. D., Mintun, M. A., Pontecorvo, M. J., Shenton, M. E. & Reiman, E. M., May 2 2019, In : New England Journal of Medicine. 380, 18, p. 1716-1725 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

Belfiore, R., Rodin, A., Ferreira, E., Velazquez, R., Branca, C., Caccamo, A. & Oddo, S., Feb 1 2019, In : Aging Cell. 18, 1, e12873.

Research output: Contribution to journalArticle

15 Scopus citations

Transcriptome Changes in the Alzheimer's Disease Middle Temporal Gyrus: Importance of RNA Metabolism and Mitochondria-Associated Membrane Genes

Piras, I. S., Krate, J., Delvaux, E., Nolz, J., Mastroeni, D. F., Persico, A. M., Jepsen, W. M., Beach, T. G., Huentelman, M. J., Coleman, P. D. & Combs, C., Jan 1 2019, In : Journal of Alzheimer's Disease. 70, 3, p. 691-713 23 p.

Research output: Contribution to journalArticle

2 Scopus citations

Transcriptomic Network Interactions in Human Skin Treated with Topical Glucocorticoid Clobetasol Propionate

Lili, L. N., Klopot, A., Readhead, B., Baida, G., Dudley, J. T. & Budunova, I., Jan 1 2019, (Accepted/In press) In : Journal of Investigative Dermatology.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

Velazquez, R., Ferreira, E., Tran, A., Turner, E. C., Belfiore, R., Branca, C. & Oddo, S., Jan 1 2018, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

13 Scopus citations

Correction to: Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden (Molecular Psychiatry, (2018), 10.1038/s41380-018-0255-6)

Haure-Mirande, J. V., Wang, M., Audrain, M., Fanutza, T., Kim, S. H., Heja, S., Readhead, B., Dudley, J. T., Blitzer, R. D., Schadt, E. E., Zhang, B., Gandy, S. & Ehrlich, M. E., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations

Corrigendum to “Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease” [Neurobiol. Aging 58 (2017) 1–13](S0197458017301999)(10.1016/j.neurobiolaging.2017.06.003)

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K. T., May 1 2018, In : Neurobiology of Aging. 65, p. 235-238 4 p.

Research output: Contribution to journalComment/debate

Erratum to: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia (Nature Communications, (2018), 9, 1, (4412), 10.1038/s41467-018-06515-4)

Readhead, B., Hartley, B. J., Eastwood, B. J., Collier, D. A., Evans, D., Farias, R., He, C., Hoffman, G., Sklar, P., Dudley, J. T., Schadt, E. E., Savić, R. & Brennand, K. J., Dec 1 2018, In : Nature communications. 9, 1, 4926.

Research output: Contribution to journalComment/debate

1 Scopus citations

Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

Readhead, B., Hartley, B. J., Eastwood, B. J., Collier, D. A., Evans, D., Farias, R., He, C., Hoffman, G., Sklar, P., Dudley, J. T., Schadt, E. E., Savić, R. & Brennand, K. J., Dec 1 2018, In : Nature Communications. 9, 1, 4412.

Research output: Contribution to journalArticle

12 Scopus citations

Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease

Caccamo, A., Belfiore, R. & Oddo, S., Aug 1 2018, In : Neurobiology of Aging. 68, p. 59-67 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

Research output: Contribution to journalArticle

87 Scopus citations

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS

the CommonMind Consortium, Jun 7 2018, In : American Journal of Human Genetics. 102, 6, p. 1169-1184 16 p.

Research output: Contribution to journalArticle

19 Scopus citations

Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain

Mastroeni, D., Nolz, J., Sekar, S., Delvaux, E., Serrano, G., Cuyugan, L., Liang, W. S., Beach, T. G., Rogers, J. & Coleman, P., Mar 1 2018, In : Neurobiology of Aging. 63, p. 12-21 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

Readhead, B., Haure-Mirande, J. V., Funk, C. C., Richards, M. A., Shannon, P., Haroutunian, V., Sano, M., Liang, W. S., Beckmann, N. D., Price, N. D., Reiman, E. M., Schadt, E. E., Ehrlich, M. E., Gandy, S. & Dudley, J. T., Jul 11 2018, In : Neuron. 99, 1, p. 64-82.e7

Research output: Contribution to journalArticle

135 Scopus citations

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

Mastroeni, D., Nolz, J., Khdour, O., Sekar, S., Delvaux, E., Cuyugan, L., Liang, W. S., Hecht, S. & Coleman, P., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

8 Scopus citations

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

Johansson, J. U., Brubaker, W. D., Javitz, H., Bergen, A. W., Nishita, D., Trigunaite, A., Crane, A., Ceballos, J., Mastroeni, D., Tenner, A. J., Sabbagh, M. & Rogers, J., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

7 Scopus citations

Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease

Tan, Y., Delvaux, E., Nolz, J., Coleman, P., Chen, S. & Mastroeni, D., Aug 1 2018, In : Neurobiology of Aging. 68, p. 134-141 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A call for new approaches to Alzheimer's disease research

Coleman, P. & Mastroeni, D., Sep 1 2017, In : Neurobiology of Aging. 57, p. iii-iv

Research output: Contribution to journalComment/debate

6 Scopus citations

ANK1 is up-regulated in laser captured microglia in Alzheimer’s brain; the importance of addressing cellular heterogeneity

Mastroeni, D., Sekar, S., Nolz, J., Delvaux, E., Lunnon, K., Mill, J., Liang, W. S. & Coleman, P., Jul 2017, In : PloS one. 12, 7, e0177814.

Research output: Contribution to journalArticle

15 Scopus citations

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K. T., Oct 1 2017, In : Neurobiology of Aging. 58, p. 1-13 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Corrigendum to “Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease” [Neurobiol. Aging 58 (2017) 1–13] (S0197458017301999) (10.1016/j.neurobiolaging.2017.06.003))

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K. T., Oct 1 2017, In : Neurobiology of Aging. 58, p. 241 1 p.

Research output: Contribution to journalComment/debate

Dyrk1 inhibition improves Alzheimer's disease-like pathology

Branca, C., Shaw, D. M., Belfiore, R., Gokhale, V., Shaw, A. Y., Foley, C., Smith, B., Hulme, C., Dunckley, T., Meechoovet, B., Caccamo, A. & Oddo, S., Oct 1 2017, In : Aging Cell. 16, 5, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Editorial: Current and Emerging Therapeutics in AD

Sabbagh, M. & DeCourt, B., Jan 1 2017, In : Current Alzheimer Research. 14, 4, p. 354-355 2 p.

Research output: Contribution to journalEditorial

Erratum: Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells (Cell Reports (2016) 15(5) (1024–1036) (S2211124716303965) (10.1016/j.celrep.2016.03.090))

Topol, A., Zhu, S., Hartley, B. J., English, J., Hauberg, M. E., Tran, N., Rittenhouse, C. A., Simone, A., Ruderfer, D. M., Johnson, J., Readhead, B., Hadas, Y., Gochman, P. A., Wang, Y. C., Shah, H., Cagney, G., Rapoport, J., Gage, F. H., Dudley, J. T., Sklar, P. & 4 others, Mattheisen, M., Cotter, D., Fang, G. & Brennand, K. J., Sep 5 2017, In : Cell Reports. 20, 10, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer's disease

Branca, C., Ferreira, E., Nguyen, T. V., Doyle, K., Caccamo, A. & Oddo, S., Dec 1 2017, In : Human Molecular Genetics. 26, 24, p. 4823-4835 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease

Norambuena, A., Wallrabe, H., McMahon, L., Silva, A., Swanson, E., Khan, S. S., Baerthlein, D., Kodis, E., Oddo, S., Mandell, J. W. & Bloom, G. S., Feb 1 2017, In : Alzheimer's and Dementia. 13, 2, p. 152-167 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's

Delvaux, E., Mastroeni, D., Nolz, J., Chow, N., Sabbagh, M., Caselli, R. J., Reiman, E. M., Marshall, F. J. & Coleman, P., Oct 1 2017, In : Neurobiology of Aging. 58, p. 225-237 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Necroptosis activation in Alzheimer's disease

Caccamo, A., Branca, C., Piras, I. S., Ferreira, E., Huentelman, M. J., Liang, W. S., Readhead, B., Dudley, J. T., Spangenberg, E. E., Green, K. N., Belfiore, R., Winslow, W. & Oddo, S., Sep 1 2017, In : Nature Neuroscience. 20, 9, p. 1236-1246 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Paving the Way for New Clinical Trials for Alzheimer's Disease

Branca, C. & Oddo, S., Jan 15 2017, In : Biological Psychiatry. 81, 2, p. 88-89 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms

Brubaker, W. D., Crane, A., Johansson, J. U., Yen, K., Garfinkel, K., Mastroeni, D., Asok, P., Bradt, B., Sabbagh, M., Wallace, T. L., Glavis-Bloom, C., Tenner, A. J. & Rogers, J., Dec 1 2017, In : Alzheimer's and Dementia. 13, 12, p. 1397-1409 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Targeting tumor necrosis factor alpha for Alzheimer’s disease

DeCourt, B., Lahiri, D. K. & Sabbagh, M. N., Apr 1 2017, In : Current Alzheimer Research. 14, 4, p. 412-425 14 p.

Research output: Contribution to journalReview article

45 Scopus citations
2016

Analysis of the putative role of CR1 in Alzheimer's disease: Genetic association, expression and function

Fonseca, M. I., Chu, S., Pierce, A. L., Brubaker, W. D., Hauhart, R. E., Mastroeni, D., Clarke, E. V., Rogers, J., Atkinson, J. P. & Tenner, A. J., Feb 2016, In : PloS one. 11, 2, e0149792.

Research output: Contribution to journalArticle

35 Scopus citations

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease

Talukdar, H. A., Foroughi Asl, H., Jain, R. K., Ermel, R., Ruusalepp, A., Franzén, O., Kidd, B. A., Readhead, B., Giannarelli, C., Kovacic, J. C., Ivert, T., Dudley, J. T., Civelek, M., Lusis, A. J., Schadt, E. E., Skogsberg, J., Michoel, T. & Björkegren, J. L. M., Mar 23 2016, In : Cell Systems. 2, 3, p. 196-208 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention

McNulty, S. N., Strübe, C., Rosa, B. A., Martin, J. C., Tyagi, R., Choi, Y. J., Wang, Q., Pepin, K. H., Zhang, X., Ozersky, P., Wilson, R. K., Sternberg, P. W., Gasser, R. B. & Mitreva, M., Feb 9 2016, In : Scientific reports. 6, 20316.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Identification of learning-induced changes in protein networks in the hippocampi of a mouse model of Alzheimer's disease

Ferreira, E., Shaw, D. M. & Oddo, S., Jul 5 2016, In : Translational Psychiatry. 6, 7, e849.

Research output: Contribution to journalArticle

5 Scopus citations