Applied Structural Discovery, Center for (ASD)

Projects

Projects per year 2009 2016 2018 2019 2020 2027

• 36 Active
• 37 Finished

Projects per year

Search results

• Finished

  Arizona Alzheimer's Consortium (AAC) FY22 - Non-Match Projects

  Fromme, P. & Coon, D.

  Arizona Department of Health Services

  7/1/21 → 6/30/22

  Project: Research project

  • project 100%

• Structural Biology of Dopamine Signaling

  Liu, W.

  HHS: National Institutes of Health (NIH)

  1/1/21 → 1/2/22

  Project: Research project

  • Dopamine 100%

• Drug Target Validation of the Enterovirus D68 2A protease

  Liu, W.

  HHS: National Institutes of Health (NIH)

  9/22/20 → 12/31/21

  Project: Research project

  • Human Enterovirus D 100%
  • Peptide Hydrolases 51%
  • Pharmaceutical Preparations 21%

• Taking Biochemistry to new heights: developing nanosatellites for protein crystallisation

  Ros, A.

  OTHER: Foreign Government

  6/1/20 → 4/30/22

  Project: Research project

  • Crystallization 100%
  • Biochemistry 74%
  • Proteins 30%

• Seeing the forces of life

  Singharoy, A.

  Gordon and Betty Moore Foundation

  2/6/20 → 5/1/22

  Project: Research project

• Visualizing chemical bonding in biological macromolecules by microcrystal electron diffraction

  Nannenga, B.

  HHS: National Institutes of Health (NIH)

  9/20/19 → 7/31/22

  Project: Research project

  • Electron Diffraction 100%
  • Macromolecule 83%

• Genetically encodable epitopes to overcome size and resolution limits in cryo-EM - Resubmission - 1

  Mills, J. & Nannenga, B.

  HHS: National Institutes of Health (NIH)

  9/15/19 → 6/30/22

  Project: Research project

  • Epitopes 100%
  • Proteins 68%
  • Nicotine 37%
  • Antibodies 36%
  • Amino Acids 32%

• The Type I Homodimeric Reaction Center in Heliobacterium modesticaldum

  Redding, K. & Fromme, R.

  DOE: Office of Science (OS)

  9/1/19 → 9/2/19

  Project: Research project

  • Bacteriochlorophyll 100%
  • Ferredoxin 98%
  • Quinone 75%
  • X-Ray Crystallography 65%
  • Site-Directed Mutagenesis 54%

• 16X118TO2 (MEDD) - P97 Project

  Fromme, P., Nannenga, B. & Chiu, P.

  HHS: National Institutes of Health (NIH)

  7/16/19 → 8/30/20

  Project: Research project

• Enabling 3D Fluorescence Imaging Under Anaerobic Environments

  Krajmalnik-Brown, R., Rittmann, B., Green, M., Torres, C., Adams, J. & Nannenga, B.

  DOD-NAVY: Office of Naval Research (ONR)

  6/1/19 → 5/31/21

  Project: Research project

  • fluorescence 100%

• Recombinant Protein Production, Purification, and Characterization

  Liu, W.

  INDUSTRY: Domestic Company

  5/14/19 → 5/7/21

  Project: Research project

  • Recombinant Proteins 100%

• What does self look like?

  Singharoy, A.

  Gordon and Betty Moore Foundation

  3/1/19 → 5/1/21

  Project: Research project

• A Biophysics pipeline between Arizona schools and Universities usingremote visu

  Singharoy, A.

  Flinn Foundation

  1/1/19 → 12/31/20

  Project: Research project

  • biophysics 100%
  • school 61%
  • visualization 23%

• Batelle Contract - Revision - 2

  Chiu, P.

  Pacific Northwest National Laboratory (PNNL)

  12/19/18 → 2/28/19

  Project: Research project

• Sub-Project 4

  Fromme, P. & Liu, W.

  Mayo Clinic Rochester

  11/1/18 → 10/31/19

  Project: Research project

• Sub-Project 1

  Liu, W. & Fromme, P.

  Mayo Clinic Arizona

  11/1/18 → 10/31/19

  Project: Research project

• Sub-Project 8

  Fromme, P. & Liu, W.

  Mayo Clinic Arizona

  11/1/18 → 10/31/19

  Project: Research project

• Sub-Project 7

  Fromme, P. & Liu, W.

  Mayo Clinic Jacksonville

  11/1/18 → 10/31/19

  Project: Research project

• Sub-Project 3

  Fromme, P. & Liu, W.

  Mayo Clinic Rochester

  11/1/18 → 10/31/19

  Project: Research project

• Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time- Resolved X-Ray Scattering

  Kirian, R. & Fromme, P.

  National Science Foundation (NSF)

  8/1/18 → 7/31/22

  Project: Research project

  • proteins 100%
  • x rays 56%
  • scattering 53%
  • light scattering 44%

• Batelle Contract

  Chiu, P.

  Pacific Northwest National Laboratory (PNNL)

  6/18/18 → 9/1/18

  Project: Research project

• Differentiation of Mutant Virus Particles

  Hayes, M. & Hogue, B.

  HHS: National Institutes of Health (NIH)

  5/15/18 → 4/30/21

  Project: Research project

  • Virion 100%
  • Viruses 69%
  • Sindbis Virus 50%
  • Venus 27%
  • Lab-On-A-Chip Devices 23%

• System Level Simulation of a Bioenergetic Membrane

  Singharoy, A.

  HHS: National Institutes of Health (NIH)

  5/1/18 → 6/30/19

  Project: Research project

  • Energy Metabolism 100%
  • Membranes 73%
  • Proteins 36%
  • Adenosinetriphosphate 25%
  • Students 14%

• Structural Investigation of the Integrin av8 in its Role in TGF- Activation

  Chiu, P.

  INDUSTRY: Domestic Company

  8/1/17 → 7/31/18

  Project: Research project

  • activation 100%

• Structure and Function of Dopamine Receptors

  Liu, W.

  HHS: National Institutes of Health (NIH)

  3/15/17 → 2/28/20

  Project: Research project

  • Dopamine Receptors 100%
  • Substance-Related Disorders 70%
  • Ligands 68%
  • Drug Design 36%
  • G-Protein-Coupled Receptors 32%

• Mayo-ASU Structural Biology Alliance Program projects 7-8

  Fromme, P. & Liu, W.

  Mayo Clinic Rochester

  10/1/16 → 10/31/19

  Project: Research project

  • biology 100%

• Mayo-ASU Structural Biology Alliance Program projects 3-4

  Fromme, P. & Liu, W.

  Mayo Clinic Rochester

  10/1/16 → 10/31/19

  Project: Research project

  • atrial natriuretic factor receptor A 100%
  • Metabolic Diseases 65%
  • Drug Delivery Systems 61%
  • Triglycerides 49%
  • Cardiovascular Diseases 45%

• Mayo-ASU Structural Biology Alliance Program projects 1-2

  Liu, W. & Fromme, P.

  Mayo Clinic Rochester

  10/1/16 → 10/31/19

  Project: Research project

  • Drug Design 100%
  • Immunoglobulins 76%
  • Obesity 60%
  • Therapeutics 14%

• Mayo-ASU Structural Biology Alliance Program projects 5-6

  Liu, W. & Fromme, P.

  Mayo Clinic Rochester

  10/1/16 → 10/31/19

  Project: Research project

  • von Willebrand Factor 100%
  • Receptor Protein-Tyrosine Kinases 97%
  • Therapeutics 14%

• Molecular Signature of Biased Agonism in G-protein Coupled Receptors

  Liu, W.

  INDUSTRY: Domestic Company

  9/29/16 → 9/29/21

  Project: Research project

  • G-Protein-Coupled Receptors 100%
  • GTP-Binding Proteins 18%
  • Ligands 13%
  • Structure-Activity Relationship 11%
  • mu Opioid Receptor 11%

• Nanopatterned Electron Beams for Coherent Radiation Emission

  Graves, W.

  National Science Foundation (NSF)

  8/15/16 → 7/31/22

  Project: Research project

  • coherent radiation 100%
  • electron beams 90%
  • x rays 62%
  • accelerators 49%
  • modulation 46%

• ABI Innovation: New Algorithms for Biological X-ray Free Electron Laser Data

  Schmidt, K., Weierstall, U. & Kirian, R.

  NSF-BIO: Division of Biological Infrastructure (DBI)

  8/1/16 → 11/30/20

  Project: Research project

  • X ray lasers 100%
  • Free electron lasers 85%

• Biology with X-Ray Lasers

  Liu, W.

  National Science Foundation (NSF)

  5/1/16 → 12/31/18

  Project: Research project

  • G-Protein-Coupled Receptors 100%
  • Lasers 90%
  • X-Rays 86%
  • Membrane Proteins 61%
  • Proteins 54%

• Nanobody Productdion for GPCR Structure-function Studies

  Liu, W.

  ASU: Mayo Seed Grant

  1/1/16 → 6/30/17

  Project: Research project

• MRI: Acquisition of Cryo-EM for Southwest Regional Center

  Westerhoff, P., Vermaas, W., Frasch, W., Roberson, R., Carpenter, R., Rez, P., Weierstall, U., Muthuswamy, J., Leket-Mor, T., Fromme, P., Hogue, B., Stabenfeldt, S., Mason, H., Yan, H., Rittmann, B., Torres, C., Wiktor, P., Rege, K., Halden, R., Ros, R., Ros, A., LaBaer, J., Olive, M., Liu, J., Van Horn, W. & Liu, W.

  NSF-BIO: Division of Biological Infrastructure (DBI)

  9/1/15 → 8/31/18

  Project: Research project

  • cryo-electron microscopy 100%
  • structural biology 87%
  • electron microscopes 80%
  • image analysis 32%
  • crystallography 28%

• Femtosecond nano-crystallography of membrane proteins

  Fromme, P., Schmidt, K., Weierstall, U. & Ros, A.

  HHS-NIH: National Institute of General Medical Sciences (NIGMS)

  6/1/15 → 2/29/20

  Project: Research project

  • crystallography 100%
  • protein 79%
  • membrane 68%
  • X-ray diffraction 14%
  • method 10%

• (Flinn-JL) Establishment of a high throughput protein production center to empower translational research in Arizona (ASUF 30005389)

  LaBaer, J. & Fromme, P.

  Flinn Foundation

  10/1/14 → 9/30/19

  Project: Research project

  • translational medical research 100%
  • proteins 33%
  • proteomics 13%
  • Biological Sciences 11%
  • drugs 5%