5TUD : Structural Insights into the Extracellular Recognition of the Human Serotonin 2B Receptor by an Antibody

  • Andrii Ishchenko (Contributor)
  • Daniel Wacker (Contributor)
  • Mili Kapoor (Contributor)
  • Ai Zhang (Contributor)
  • Gye Won Han (Contributor)
  • Shibom Basu (Contributor)
  • Uwe Weierstall (Contributor)
  • Wei Liu (Contributor)
  • Vsevolod Katritch (Contributor)
  • Raymond C. Stevens (Contributor)
  • Vadim Cherezov (Contributor)

Dataset

Description

Experimental Technique/Method:X-RAY DIFFRACTION
Resolution:3.0
Classification:SIGNALING PROTEIN
Release Date:2017-07-26
Deposition Date:2016-11-05
Revision Date:2017-08-16#2017-09-13#2018-02-14
Molecular Weight:201427.98
Macromolecule Type:Protein
Residue Count:1812
Atom Site Count:12395
DOI:10.2210/pdb5tud/pdb

Abstract:
Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs. Here we present the 3.0-Å resolution structure of a complex between the human 5-hydroxytryptamine 2B (5-HT
Date made available2017
PublisherRCSB-PDB

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